Hot/Cold Tumours8 Aug 2019 06:13
Inan/Wild/Ray, enjoyed your posts from yesterday. Been reading up on much you all spoke of in the early hours of this morning and there is so much on the internet to research too. This particular website was interesting as indeed they all were, but really explains what we are doing so well, and also explains the time we have spent in clinical development..........
https://www.nature.com/articles/s41573-018-0007-y
Abstract
Immunotherapies are the most rapidly growing drug class and have a major impact in oncology and on human health. It is increasingly clear that the effectiveness of immunomodulatory strategies depends on the presence of a baseline immune response and on unleashing of pre-existing immunity. Therefore, a general consensus emerged on the central part played by effector T cells in the antitumour responses. Recent technological, analytical and mechanistic advances in immunology have enabled the identification of patients who are more likely to respond to immunotherapy. In this Review, we focus on defining hot, altered and cold tumours, the complexity of the tumour microenvironment, the Immunoscore and immune contexture of tumours, and we describe approaches to treat such tumours with combination immunotherapies, including checkpoint inhibitors. In the upcoming era of combination immunotherapy, it is becoming critical to understand the mechanisms responsible for hot, altered or cold immune tumours in order to boost a weak antitumour immunity. The impact of combination therapy on the immune response to convert an immune cold into a hot tumour will be discussed.
So much to learn and understand, no wonder many of us struggle to keep up, but researching small segments like this does bring it home all the more. That particular Abstract was from January 2019, which should quell the fears of some that we have lost ground in this ""war on cancer"". If anything we are up there, leading the charge, and the excitement grows as human trials begin to get closer. Wonder if the Fibonacci Retracement is over? there are some very interesting articles on that too.
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