Member Info for BuenaVista

The BOIN (Bayesian Optimal Interval) design is a model-assisted, adaptive statistical method for early-phase oncology trials, used primarily to find the Maximum Tolerated Dose (MTD) by comparing the observed dose-limiting toxicity (DLT) rate with pre-set escalation and de-escalation boundaries, offering a simple, efficient, and statistically sound alternative to older methods like the 3+3 design. It's known for its transparency, operational simplicity, and strong performance in guiding dose escalation/de-escalation to safely identify the optimal dose level for further study.

Primarily used in Phase I oncology trials to find the MTD or the Recommended Phase II Dose (RP2D).

Key Advantages

• Simplicity & Efficiency: Easier for clinicians to use than complex model-based designs, while being more adaptive and faster than traditional methods.

• Improved Safety: Better overdose control, reducing patient exposure to overly toxic doses.

• Flexibility: Can handle various scenarios, including drug combinations, late-onset toxicity, and different endpoints.

• Strong Performance: High probability of correctly identifying the true MTD.

There is a series of complex (as in involving strange mathematical symbols) decision criteria. More details here:

An overview of the BOIN design and its current extensions for novel early-phase oncology trials ( https://www.sciencedirect.com/science/article/pii/S2451865422000606 )

I was worried about what effect the 7 week US government shutdown would have on CC's timelines but gladly it seems to have been minimal.

Just a reminder that Thornogson/NDN/Eggy, the ToucanOfDoom and the pub bore are only here to waste your time.

Just a reminder that Thornogson/NDN/Eggy never owned any Avacta shares and is just paid by TW to waste people's time on here.

Maybe Peel Hunt have been ditched because they are leaky and SH engaged to be tighter-lipped for any placings.

Peel Hunt seems to have been dropped as both nomad and broker. New nomad is Strand Hanson: https://www.strandhanson.co.uk/about

I don't know what this means but I am impressed with the layout and clarity of today's year-end trading update (see here for RNS with active links: https://www.londonstockexchange.com/news-article/AVCT/year-end-trading-update/17421159 ).

And I only noticed one typo, in the very last sentence!

Crude 'Trader' = Rainbow 'Trader' = Rainbow Chaser

https://www.lse.co.uk/profiles/crudetrader/

Bella wrote: "Why no mention of AVA6000 p2...?"

I can only suggest you re-read the RNS and then list the several mentions of faridox Phase 2 plans here for us.

An excellent summary of the state of play - with links to full details. If, after thoroughly digesting this RNS and linked information, 'concerned' shareholders don't understand the enormous value of what they hold and have been spooked by those who make their living spreading fear, uncertainty and doubt, then they should sell and move on; the lengthy time and many hurdles of biopharma progress isn't for you. Just be aware that share-boosting news could arrive now at any time.

We need to see what was said about ferry docks!

CC made it clear that all the preclinical work, including tox, and the GMP production need to be done before filing the IND so that everything is ready to go when approval is given. This means Avacta has been working closely enough with the FDA to know exactly what the FDA will require in that IND. The filing of the IND is unlikely to be announced as a special announcement but may be included in another announcement as a sidenote.

He's paid by TW to dis Avacta on here. No integrity, no credibility.

Yes I remember the question also but I don't think the intention was that Avacta divert valuable resources to it, although that's the way CC and MM chose to interpret it, perhaps deliberately so as to limit and then reject the idea.

I don't think anyone suggested that Avacta should develop veterinary therapeutics themselves. That would be a preposterous idea! But the tech could have been licensed out to a veterinary research organisation, assuming the IP covered that.

At least when he's on here he's not out bothering nurses.

See what a social service we are providing by entertaining his spurious arguments and delusions of grandeur!

Just a reminder that Toukankahmoon is angry because he got spiked, twice.

Sterling work there B2H! And no ferry docks anywhere to be seen!

Tbf, I added the "Really, nothing more needs to be said." after inserting a - - - - - break line.

But, anyway... Really, nothing more needs to be said.

🥱

Just a reminder that Thornogson/NDN/Eggy has never been invested in Avacta and works for TW to undermine sentiment here with constant talk about his spurious 'half-life issue'.