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"Cohort V delivered Doxorubicin at x2.2 normal levels. Cohorts VI will commence early July and deliver Doxorubicin at x2.7 normal levels."

It is actually 2.25x and 2.79x the doxorubicin contained in the 75mg/m² doxorubicin dose.

Interim data may not be published part-way through Phase 1b but if the doxorubicin patients are switched to AVA6000 after, say 4 cycles (12 weeks), for ethical reasons because the improved efficacy, reduced side-effects and lack of cardiotoxicity of AVA6000 is so much better then I guarantee that would be RNSed and everyone can then draw their own conclusions about AVA6000 efficacy.

Anyway, Phase 1a will, pre-data publication and under NDAs for prospective licencees, give some qualitative data on efficacy and side-effects and (statistically) limited quantitative data (from bi-cycle tumour monitoring) on disease progression and any regression. Marry that with AVA3996 preclinical data correlated with AVA6000 preclinical data and compared to AVA6000 clinical data and the pharma companies should be chomping at the bit. Best deal for first mover? Floodgates then open?

Re: https://www.philogen.com/philogen/wp-content/uploads/2022/10/20221014_Philogen_OncoFAP_Clinical_PR.pdf

Philochem AG patents for this date from 19 August 2021, so a long way from commercialisation.

https://patentscope.wipo.int/search/en/result.jsf?_vid=P20-LJVD4Z-12901

Tech seems to be a big protein (OncoFAP) linked via the peptide Gly-Pro to a cytotoxic, the favoured one of which is monomethyl auristatin E (MMAE), a dolastatins derived from marine moluscs and not, as far as I can see, authorised for use yet. MMAE is so toxic that drugs in development have to be masked with an antibody and be directed to the site of action.

https://go.drugbank.com/metabolites/DBMET02167

Apologies, I meant https://www.youtube.com/watch?v=CiHYIrrgktc&ab_channel=InvestorMeetCompany slide 17 (@29:07)

🤣 Had to add my rec when you said Icecool doesn't "add value and knowledge to the board ".🤣🤣🤣

😎

For the pre|CISION pipelineintheir online presentations?

Paciltaxel - No, the pre|CISION compound has to be an analogue

Oxaliplatin - A prodrug of this compound or an analogue?

Germcitabine - Small molecule with a free -NH2 group, so obvious

Capecitabine - No, it has to be an analogue

Balixafortide - Wow! A complex molecule but it does have an available -NH2 group

Unless they, or Bachovchin, have patented the pre|CISION pipeline of anticancer prodrugs, those above that have been disclosed (in presentations) and are obvious will have no patent protection.

https://avacta.com/wp-content/uploads/2021/11/IWC-2021-Avacta-Presentation.pdf slide 14

"I'd like to know whether or not the continuing patients remain on their C5 dosage or will they be bumped up to the C6 2.7 level? Wouldn't it be fantastic news ......to go from non-progression to healing."

Question 1: What would it tell you if their tumour was controlled on dose A and they were "bumped up" to dose B?

Question 2: What would it tell you if their tumour was controlled on dose A and they continued on dose A?

"So if they are running in tandem that means the US cohort 5 was completed in 55 days."

No.

It. is. the. same. cohort. THERE IS ONLY ONE COHORT 5. Is it so very difficult to understand that a patient in the US on 250mg/m² is the same as a patient in London or Manchester on 250mg/m²? No wonder RAH got so many recs for his fantasy sh ite when so many here haven't the first clue about how the pharma industry works.

Yes, that's also a warning about believing anything the fantasist RAH posts.

It's a sign!

Life is too short for this banality. notrex binned.

There has been an understandable trend in recent years to more sophisticated, more complex medications as the low hanging fruit has been picked and largely found to not be very satisfactory in reversing cancer. The modern treatments are VERY expensive. In this landscape, the pre|CISION technology is a no brainer as long as the prodrug - the drug+leaving group conjugate - is shown to be inert other than cleavage by FAP. Impossible to put a valuation on this but it will be very high.

Caribou Biosciences Announces $25 Million Equity Investment from Pfizer

https://www.marketwatch.com/press-release/caribou-biosciences-announces-25-million-equity-investment-from-pfizer-4118785c?mod=mw_quote_news_seemore

Investment comes from Pfizer (PFE) in the form of a stock purchase that saw Pfizer buy 4.69 million shares for $5.33 apiece.

SP shot up some 60%, finished the day 46% up.

Caribou have two CAR T cell candidates in Phase 1 for blood cancers.

Correct 13th. The chemistry requires a conformationally suitable -NH2 group on the drug in order to form a peptide bond with the -CO2 of the L-Pro in the linker.

Background for FAP and RA (and OA?)

Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes

https://pubmed.ncbi.nlm.nih.gov/17105646/

FAP isn't just upregulated in tumours, it is also present in high numbers in other conditions. The AVA6000 actually lists the conditions:

"Disclosed are prodrugs of cytotoxic anthracyclines (such as doxorubicin) and other therapeutic agents that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful for targeted delivery of cytotoxic and other agents to FAP- expressing tissues, including cancer (e.g., solid tumors). Also provided are pharmaceutical compounds comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation, e.g., cancer, fibrosis, and inflammation."

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015192123

I'm not familiar with modes of action but if, say, you have a powerful rheumatoid arthritis drug that acts at the site of arthritic inflammation but has unacceptable side-effects elsewhere in the body, then that might be a suitable candidate to present as a prodrug using the pre|CISION platform.

Thanks PL. The idiot minnabo now binned for propagating the lie.

Eh? 93% long? What's that supposed to mean?

This isn't from the Avacta website.

https://avacta.com/careers/careervacancies/

Old vacancy.

https://web.archive.org/web/20230602074107/https://avacta.com/careers/careervacancies/

12 April tweet.

https://twitter.com/tom_the_bomb__/status/1646123543317426178

Is this in an email from Avacta?

Did your work colleague's husband ask the cleaners? If anyone in a huge hospital knows what's going on in every room it'll be the cleaners. Or work colleague should tell him if that he can't find a cleaner he should look out for the 12ft posters proclaiming "AVA6000 IS THE NEW ANTICANCER DRUG EVERYONE IS TALKING ABOUT".🙄