"Most licencing deals signed at early stage" - JP Morgan16 Jul 2024 07:34
It's well worth pointing out that big pharma sign the majority of their licencing deals at the earliest stages, as this data from JP Morgan highlights:
* The largest share of in-license deals into big pharma happens at platform and discovery stages. i.e. Genedrive's MT-RNR1 ID Kit & CYP2C19-ID kit.
* These provide the partners substantial support and control over programme development.
* Deals signed at these earliest stages saw median upfront payments of $45 million in 2023.
* Large-cap biopharma (market cap of $50 billion-plus) are still signing $100 million-plus deal upfronts. Median upfront values increased for Platform / Discovery stage programmes as well, reaching $47 million.
Here are some of the biggest recent licencing deals :
* Akeso paid $500 million upfront by Summit Therapeutics in 2023 to in-license ivonescimab. Additionally, the partnership outlines a potential deal value of up to USD 4.5 billion.
* Alnylam received an upfront cash payment of USD 310 million from Roche (the company GDR's CEO James Cheek used to work for) in 2023 to co-develop and co-commercialize Zilebesiran. Additional development, regulatory, and sales milestones could potentially elevate the deal value to USD 2.8 billion.
* Evotec was paid $50 Million upfront in 2023 by Bristol Myers Squibb. Tiered royalties on product sales further underscore the financial commitment, resulting in USD 4bn potential deal value.
* Kelun-Biotech was paid an upfront $175 Million by Merck in 2023 to co-develop preclinical antibody-drug conjugates. Future development, regulatory, and sales milestone payments, which could total up to USD 9.3 billion.
Source: https://www.jpmorgan.com/content/dam/jpm/commercial-banking/insights/life-sciences/jpmorgan-chase-q3-2023-biopharma-final-ada_v2.pdf
So, rather than GDR going it alone it could be that a major player steps in to either licence Genedrive's MT-RNR1 ID Kit & CYP2C19-ID kit or a takeover happens. Either way, based on these multi million deals GDR shareholders will benefit significantly....
Good luck, Brighty