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Skeletor

No, because those who arrive in hospital will have not mounted a sufficient interferon response.

I'm doing the Gladiators show with Scorpio

Via P(MJH) on twitter...

https://twitter.com/1985muenchen/status/1493964056260194309?t=z5vLSm-7aUa7J0gm2rFeoA&s=19

'Novartis has put out a plea for small biotechs to swim toward its $154 billion pool. '

The below from detective AIM

https://twitter.com/AIMdective/status/1493972769284972550?t=QsMjVh1k5vt_m42PsfW7aA&s=19

The Novartis angle is interesting. They supply Extavia, an injectable 1b product being investigated in France by Dr Mary.

'Novartis have an injectable product, already manufactured at scale, that has a new potential use in inhaled form. Does this add motive? #SNG'

It my assumption that any M&A or JV RNS would be published as soon as any deal is signed, intraday or otherwise? Happy to be corrected.

Go on then lads I know you are bursting to let us in on what the secret squirrel club knows ;-)

An interesting read re interferon from the NYT in 1982. Shows just how long in the making this scientific breakthrough has been...

https://www.nytimes.com/1982/11/14/magazine/stalking-the-common-cold.html

'In the quarter-century since interferon was discovered by researchers in Britain, scientists have still not fully explained what makes it so devastatingly effective against viruses (the initial results were so startling that many virologists refused to believe them, derisively dubbing the new protein ''imaginon''). They theorize that a tiny bit of interferon locks on to a special receptor on the surface of a cell; from this outside site, it orders the cell to construct a new cellular messenger - RNA - and the new RNA in turn constructs inside the cell a yet-undiscovered protein that actually combats the virus.'

Just can't resist - like moths to an outhouse light.

'Remember, until SG016 the company thought “at home” patients were the main target - and it may well turn out that way given the ambiguities resulting from that trial'

This is false.

The home trial successfully demonstrated that SNG001 could be self-administeed with medical support via zoom.

He references SAB being 'already there' so I've taken it as that.

Should probably rename this thread to 'if it wasn't for the US, full stop'

Phase three for SNG starting 'soon' - straight from the horses mouth.

The data has become overwhelming...

'Interferon signaling is increased in COVID-19 patients and thought to contribute to host protection30,31,32,33,34. We explored whether type I interferon signaling among the B-cells and plasmablasts was associated with survival. Among these populations, naive B-cells and plasmablasts expressed ISGs in COVID-19 patients. We combined canonical ISGs from the B-naive and plasmablast DGE analyses to create a collective ISG z-score (IFIT3, ISG15, IFI6, MX1, IFI44L, ISG20, IFITM1, IFI27). Surprisingly, UMAP embedding plots and direct comparison of z-scores showed an increase in ISG expression in B-naive cells from the deceased cohort but an increase in this signature in plasmablasts from patients who survived (Fig. 3i). These findings highlight the significance of interferon signaling in distinct cell states and types with respect to survival in critical COVID-19 patients'

Not implying it's any of these trades, but SYGGF trades also appear on LSE as 'Unknown'

It was a few weeks ago a series of repeated trades for 2k odd shares went through and some American chap posted the same on twitter, noting that an ii was loading up on SYGGF - times and # of shares matched perfectly.

As shared by Welsh Falcon earlier...

What would be really funny is if these guys are legally 'independent contractors' and have to cover their own legal fees...

'Nighthawk Energy (LON:HAWK, OTC:NHEGY) is considering legal action against ‘de-rampers’ who have been making “persistent defamatory and untrue postings” on bulletin boards, hosted on the Interactive Investor (iii) and ADVFN (ADVFN) websites.

The postings concern the operations of Nighthawk and its management which the board considers to be extremely damaging to the company and its reputation.

After it obtained a High Court of Justice order in June, instructing iii and ADVFN to provide the posters’ details - who were posting material that the court accepted could be defamatory -, Nighthawk said it has now established the posters’ identities and it is considering, with its legal advisers, instituting civil proceedings against the ‘de-rampers’ for defamation.

“The company took steps to identify the posters who try to escape liability for their defamatory postings by hiding behind a cloak of anonymity ... In some cases the names and other details used to register these accounts are fictitious and posters also can try and cover their tracks using numerous pseudonyms but they can be traced through their IP addresses”.

Both iii and ADVFN are assisting Nighthawk to provide the posters’ details.

In a separate statement, Nostra Terra Oil and Gas (LON:NTOG) revealed that it is also mulling civil proceedings against certain bulletin board posters.

The company is considering its next move in response to “untrue and malicious statements about the company's activities and personnel”, which it claims have been “made repeatedly by certain posters” on the internet and via the iii and ADVFN boards.

Like Nighthawk, Nostra Terra obtained a High Court of Justice order instructing iii and ADVFN to provide information relating to the bulletin board posters.'

https://www.proactiveinvestors.com/companies/news/16434/xtract-energys-kyrgyz-jv-gets-approval-to-drill-exploration-well-16434.html

It has positive implications for SNG001 well, well beyond Covid.

But you keep doing everything you can to sew that doubt....

Looks to be a newly published study, full details behind a paywall, but the summary seems pretty good if you've got a product that can deliver INFb to the human body without the side effects associated with subcutaneous administration...

" Highlights
•
IFNß synergizes with CTLA-4 Ig to prolong allograft survival by promoting Treg cells
•
IFNß directly acts on T cells to enhance Treg cell induction
•
IFNß activates STAT1 signaling to promote P300 expression and increase Foxp3 acetylation

Summary

Type I interferons (IFNs) are pleiotropic cytokines with potent antiviral properties that also promote protective T cell and humoral immunity. Paradoxically, type I IFNs, including the widely expressed IFNß, also have immunosuppressive properties, including promoting persistent viral infections and treating T-cell-driven, remitting-relapsing multiple sclerosis. Although associative evidence suggests that IFNß mediates these immunosuppressive effects by impacting regulatory T (Treg) cells, mechanistic links remain elusive. Here, we found that IFNß enhanced graft survival in a Treg-cell-dependent murine transplant model. Genetic conditional deletion models revealed that the extended allograft survival was Treg cell-mediated and required IFNß signaling on T cells. Using an in silico computational model and analysis of human immune cells, we found that IFNß directly promoted Treg cell induction via STAT1- and P300-dependent Foxp3 acetylation. These findings identify a mechanistic connection between the immunosuppressive effects of IFNß and Treg cells, with therapeutic implications for transplantation, autoimmunity, and malignancy."

https://www.cell.com/immunity/ppt/S1074-7613(22)00040-1.ppt

Crisis = Opportunity

Of all the very well thought out posts and points on this thread, I think the most relevant is this one from Trek

'There primary fear comes from the Ukrainian’s themselves. How much of a fight will they put up. Their history is littered with hatred for Moscow not just from the 4m deaths in the 1930’s Stalin years from forced famine and starvation. Their worry is the body bags from Ukraine not the West’s empty threats.

It’s the fight from Ukraine that is the concern hence the huge numbers of troops that they will need.'

Russian boots on the ground in Kiev means NATO can funnel arms, money and CIA operators in to Ukraine. With a sizable % of the population ready to resist, the result will be Russia deep in quagmire very quickly.

Add in sanctions, robbing Putin of Ogliarch support and the potential to stir **** up on other frontiers (the Caucasus, central Asia, the Pacific) and it would be a suicidal move for the Putin regime.

I have to expect the paramount to Putin is the status quo domestically, I just see too much risk for it to happen.

Oak, BC - agree on both.

Wouldn't normally get involved in this conversation but since it's the weekend...

I Think the NATO countries telling their citizens to evacuate Ukraine, nominal troop deployments to Poland, saying it could happen 'before the Olympica are over' etc, is an attempt to call Putin's (potential) bluff and turn up the pressure.

The thing with all that russian investment, property etc in the west is it's a double edged sword - they invade they can kids goodbye to the Chelsea football clubs, the mayfair mansions and the like. Would also expect to see more of what we did in Kazakhstan a few weeks back.

I put the probability of a genuine invasion at about 20%, imho.

Here?

https://maps.app.goo.gl/8x2Phy3xfD9MvEa46