@DrEricDing22 Dec 2020 09:37
Eric Feigl-Ding
@DrEricDing
6) The N501Y mutation is problematic for other reasons too (see thread
branches above in #2 and #3 for more). And the 69-70 amino acid deletions also tricky—it’s near the critical N-terminal domain, and near where monoclonal antibodies (think MAB drugs like Regeneron) binds.
Eric Feigl-Ding
@DrEricDing
·
26m
4) The new UK
Flag of United Kingdom
and South Africa
Flag of South Africa
mutations are worrisome though, especially their implications for convalescent plasma and monoclonal antibodies. Detailed discussion why below in this master thread
Thread
Down pointing backhand index
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Eric Feigl-Ding
@DrEricDing
· Dec 21
Round pushpin
Mutation “feat never seen before”...
UPDATE on UK
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strain of #SARSCoV2 & how it evolved so fast:
Variant B.1.1.7 (aka VUI-202012-01) has 23 mutations—but acquired suddenly 17 mutations “all at once”—which experts say is *a feat never seen before*.
Thread
https://sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclear
Show this thread
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Eric Feigl-Ding
@DrEricDing
·
8m
5) one mutation creates an amino acid change at 501, which lies within the critical RECEPTOR BINDING DOMAIN (ie the “docking sites” on the spike to human receptor). Look
Eyes
in 3D where the damn N501Y mutation is—right *inside a docking site*!
Functional mutation? Unclear yet.
Image
Image
Eric Feigl-Ding
@DrEricDing
Replying to
@DrEricDing
6) The N501Y mutation is problematic for other reasons too (see thread
Thread
branches above in #2 and #3 for more). And the 69-70 amino acid deletions also tricky—it’s near the critical N-terminal domain, and near where monoclonal antibodies (think MAB drugs like Regeneron) binds.
9:31 AM · Dec 22, 2020·Twitter for iPhone
https://twitter.com/DrEricDing/status/1341315524337262592
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