Member Info for Borsaci06

@tripdatabase
New2Trip: Safety & efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: randomised, double-blind, placebo-controlled, phase 2 trial

https://cdei.ca/database/monk-interferon-beta-1a

you have the same tone with those 2 twitter posters bashing sng on that platform

" they are also effectively turning that country into a living laboratory "

“You are essentially maximizing the opportunity for the virus to learn about the human immune system. Learn about antibodies. Learn how to evade them,”

https://www.statnews.com/2021/01/04/britain-takes-a-gamble-with-covid-19-vaccines-upping-the-stakes-for-the-rest-of-us/

for all your info:

waiting to see if / when sng001 will be in these protocols as a new treatment for covid19, copd, asthma & broad spectrum of viral infections since 14.12.2017

Covid-19: WHO-sponsored preliminary review indicates Ivermectin effectiveness
https://swprs.org/who-preliminary-review-confirms-ivermectin-effectiveness/

@ClareCraigPath
Really positive news here from Liverpool University on Ivermectin treatment. (Odd that the UK, which usually leads on clinical trials, has done nothing on this thus far)
Ivermectin meta-analysis by Dr. Andrew Hill
Dr. Andrews Hill's Ivermectin meta-analysis, from University of Liverpool, England, supported by The Access to COVID-19 Tools (ACT) Accelerator.Presentation ...
https://www.youtube.com/watch?v=yOAh7GtvcOs&feature=youtu.be
7:57 AM · Jan 2, 2021·Twitter Web App

Ivermectin is officially approved as a Covid-19 treatment in Macedonia as of today.
If the indications in the local press are correct, Bulgaria will follow this week.
https://translate.google.com/translate?sl=auto&tl=en&u=https://www.vecer.press/%25d0%25b1%25d0%25be%25d0%25bb%25d0%25bd%25d0%25b8%25d1%2582%25d0%25b5-%25d0%25be%25d0%25b4-%25d0%25ba%25d0%25be%25d0%25b2%25d0%25b8%25d0%25b4-%25d1%259c%25d0%25b5-%25d1%2581%25d0%25b5-%25d0%25bb%25d0%25b5%25d1%2587%25d0%25b0%25d1%2582-%25d1%2581%25d0%25be-%25d0%25b8%25d0%25b2%25d0%25b5%25d1%2580%25d0%25bc/

Dr. Cole
@Cole44749821
Replying to
@tomhfh
NO LOCKDOWNS NEEDED!!
NO EARLY PRISON RELEASE NEEDED!!
Real Science.

99+% Effective Meds are:
Hydroxychloroquine
Zinc
Azithromycin
Dexamethasone
Ivermectin
Favipiravir
Chloroquine
COVID-19 plasma
RLF-100
Interferon beta
Niacin
Budesonide

Politicians know this but do nothing.
11:02 AM · Jan 5, 2021·Twitter Web App
https://twitter.com/Cole44749821/status/1346411792260587523

Have a look at these protocols developed and Updated by Paul Marik for:

* Prophylaxis & early outpatient treatment for covid-19
https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-I-MASK-Protocol-v7-2020-12-27-ENGLISH.pdf

* Hospital Treatment for COVID-19
https://covid19criticalcare.com/math-hospital-treatment/pdf-translations/

Experience in bringing new products to global markets

Prof Francois Balloon from University College London, said:
"The E484K mutation has been shown to reduce antibody recognition.
As such, it helps the virus SARS-CoV-2 to bypass immune protection provided by prior infection or vaccination."

https://twitter.com/TradeFloorAudio/status/1346068121904427010

@TradeFloorAudio
**** YIKES ****

UK scientists worried vaccines may not work on South African coronavirus variant ... ITV NEWS

Scientists are not fully confident that COVID-19 vaccines will work on a new variant of the coronavirus found in South Africa
https://uk.reuters.com/article/uk-health-coronavirus-britain-south-afri/uk-scientists-worried-vaccines-may-not-work-on-south-african-coronavirus-variant-itv-idUKKBN2990T2

Robert Peston
@Peston
According to one of the government's scientific advisers,
the reason for @MattHan****
's "incredible worry" about the South African Covid-19 variant is that
they are not as confident the vaccines will be as effective against it as they are for the UK's variant.

@RolandBakerIII
Could a non-segmented RNA virus rapidly evolve to evade a polyclonal immune response, rendering a vaccine ineffective?

@3PIDEMIOLOGY
Replying to
@RolandBakerIII

Yes, this is what I have read and
what @Baric_Lab said himself - that
vaccines are utterly useless against these coronavirus spike proteins...

https://twitter.com/3PIDEMIOLOGY/status/1345846011214913543

Thomas Christie Williams
Paediatrician and researcher in evolutionary genetics • @NHS_Lothian

@Williams_T_C
as with other viruses, if you grow SARS-CoV-2 in the presence of a monoclonal antibody, the virus will mutate to evade these

the virus can with just 3 mutations (in this case, deletion and insertion in two of the NTD loops and an E484K substitution in the RBD) escape from neutralisation by that plasma

https://twitter.com/Williams_T_C/status/1345708292308348931
https://twitter.com/SciVirusGuy/status/1345744751509733377

Any changes to the furin site during passage through Vero E6 cells? Concerns if I were a reviewer- exclusive use of Veros. Virus uses alternative proteases/entry in Veros and
can replicate to high titer in the absence of IFN- may explore more sequence space than in nature?
2:52 PM · Jan 3, 2021·Twitter for iPhone

It appears Covid19 is actively attacking human immune system.

The timeline appears to be about 10-12 months in which the immune system is destroyed based on when these people test positive
https://archive.4plebs.org/pol/thread/298411830/

SARS-CoV-2 M protein mutation may provide guidelines for future production of M-defective mutant SARS-CoV-2 virions, which would contribute to our understanding of SARS-CoV-2 M in antagonizing IFN production........

Administration of type I or III IFNs alone or in combination with other drugs results in
a reduced virus titer,
a limited inflammatory response,
and mild clinical disease
in both animal models and patients infected with SARS-CoV-1 or SARS-CoV-2.
Multiple proteins encoded by coronaviruses have been shown to counteract the IFN response, although the detailed action mechanisms of most of these proteins have not been well documented.
An improved understanding of the viral IFN antagonists involved in SARS-CoV-2 pathogenesis has important implications for the development of new antiviral drugs and vaccines.

This study was the first to investigate the function of the SARS-CoV-2 M protein in counteracting IFN-mediated innate antiviral immunity and its role in viral replication.
Our investigation extends the understanding of strategies employed by SARS-CoV-2 to evade antiviral immunity and provides novel mechanistic insight into the mechanisms by which coronavirus M proteins inhibit IFN production, thus shedding light on the interactions between human antiviral immunity and SARS-CoV-2 infection in the pathogenesis of COVID-19.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768267/

@nanogenomic

SARS-CoV-2 Orf6 appears to hijack nuclear import machinery, inhibiting nuclear translocation of key signaling and cell proliferation molecules such as STAT1 and STAT2. This is another way that SARS-CoV-2 downregulates intracellular immune responses such (e.g. interferon --).

These findings also meld with prior data demonstrating nuclear translocation of SARS-CoV-2. Coupled, these data suggest that the virus has evolved multiple mechanisms for avoiding both extracellular adaptive immune responses, as well as intracellular immunity / host defenses.

These findings could also lead to future discoveries about the genesis and pathogenesis of "long COVID" and repeat infections, coupled to the discovery of SARS-CoV-2 building up deep in tissues that are not as accessible to the immune system.

TL;DR: SARS-CoV-2 is a stealthy m*fer! Stay safe and take this virus seriously, even if you've gotten a vaccine or have recovered from #COVID19 already.
10:57 PM · Dec 30, 2020·Twitter Web App
https://threadreaderapp.com/thread/1344417054582059008.html

More children and adults under the age of 40 die of a brain tumour than any other cancer
We need your help to add 100,000 signatures to our petition by the February 6th 2021

Please sign our petition
https://www.braintumourresearch.org/campaigning/brain-tumour-research-petition#signnow

https://twitter.com/Bullish_Doji/status/1343920783349858304
https://twitter.com/Bullish_Doji/status/1343920783349858304
https://twitter.com/Bullish_Doji/status/1343920783349858304

Pharmaxis
@Pharmaxis
Today we’ve banked a US$7m milestone payment following the recent FDA decision approving the drug @Pharmaxis
developed for cystic fibrosis. Another US$3m is payable by our licensee when we ship 1st commercial launch stock of Bronchitol, scheduled for Q1 21