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"We are at the very start of the value curve for Avacta" AS
Sometimes it is important for investors to take a breath, step back from the market’s day-to-day ramifications and instead focus on the big picture.
Back in August 2021, Avacta dosed its first patient with AVA6000 (a tumour targeting prodrug being developed to treat soft tissue sarcomas) at the UK's Royal Marsden hospital. The primary goal was to test the drug’s safety tolerability and wider FAP-activated preCISION platform in reducing systemic toxicity of doxorubicin in humans.
Two years and four months on, the results so far from this multi-centre international Phase 1a clinical trial have been truly phenomenal.
Today the company said that AVA6000 had shown outstanding safety characteristics across all 7 cohorts – the last one being conducted at a concentration level 3.5x greater than standard doxorubicin. Indeed, so good is the prodrug at shielding healthy tissues from adverse side-effects that no upper bounds to its usage (ie Maximum Tolerated Dose) have yet been found. Which is frankly remarkable.
Importantly too, this potentially opens the door to dosing patients more frequently, as well as at higher levels or for longer cycles than has ever been allowed before.
But that’s not all.
Way beyond even the trial's original design, both AVA6000 and the preCISION platform have also demonstrated "encouraging preliminary clinical signs of anti-tumour activity", validating the mechanism of cleaving the cytotoxic solely within high FAP tumour microenvironments - and crucially not elsewhere in the body (eg triggered by other human enzymes).
Indeed, a 59-year-old male with Undifferentiated Pleomorphic Sarcoma has already experienced a significant 65% reduction in tumour volume with a duration of response >6 months and ongoing. Elsewhere, a number of other patients with different cancers have seen smaller reductions in tumour volume or stable disease.
So what does all this mean?
Well to me (as a layman), today’s Phase 1a data release further rubber stamps the scientific efficacy of the preCISION platform, and strongly suggests it can be applied across a broad range of other chemotherapies and new, more potent cytotoxins - together a multi $bn per year addressable market.
Group Eleven Resources CEO calls drill-hole results at Ireland's Stonepark project 'spectacular'
EUA top of the leaderboard.......not seen that for some time!
Thriller! :-)
Hoochy??!!!!
Sorry if it’s already been posted earlier but pls could someone share a link to the broker note?
Many thanks!
……Fairytale of New Jorc
Come on Eurasia, make this a Winter’s Tale !!
Ian, please can you put me down for Friday too? My first guess but I fancy this one! Good luck all GLTH
30 just hit per Google!!
Seasick - Good call - Where are you? Let's be havin' you!!! :-)
- 2.5m at 12.13g/t gold, including 51.6g/t gold over 0.5m
- Ongoing drilling showing positive indications in subsequent holes
John Teeling, Chairman commented: "This is a spectacular result from Hole 7 in the Tombreen Main anomaly. The 51.6g/t grade is the highest we have ever discovered in Mine River. This hole is about 42 metres southwest of Hole 4 which returned 9.11 g/t over 0.5 of a metre.
"While awaiting laboratory analysis I can report good indications in Holes 8 and 9. Hole 8 is drilled in Tombreen West 900 metres west of Hole 7. The targets are an extension of the gold zone and to look for gold veins between 50 and 200 metres. Visual observation shows the mineralisation we are looking for both above and below 100 metres. The core is in the laboratory.
"We then moved the rig to Hole 9, an untested anomaly about 350 metres southwest of Hole 7 and about 800 metres southeast of Hole 8. This anomaly showed excellent results from XRF testing. The recently completed hole shows multiple veins throughout. A step out hole will be commenced immediately while the core from Hole 9 is analysed and plans are underway to obtain approval for two holes directly east of the Hole 7 discovery.
"Because of the good results coming from three areas we are undertaking a trenching programme on two additional anomalies, B and C, to the south of Tombreen West and southwest of Tombreen Main."
We've struck gold :-)
Seems it's still ticking up, fingers crossed to break 1p soon!!
We're gonna need a bigger rocket!
Rums all round
Is there any way we can confirm DLA and UBS are still on board and working towards a great conclusion?
How can you participate in this IPO?
Thanks!
ToonArmy....washed down with the finest grog I assume?
I’ve been looking at Cardano, trying to decide if there’s good upside here - anyone else in or looking to invest?
Newbie here....reading through the posts it seems that it would be a no brainer to invest any spare cash here...correct or am I missing something?
Thx