RE: Application15 Apr 2021 09:51
Hi Mathurin,
Believe a lot of the investigations are still in its infancy as per the latest RNS. Good to see the company has strong pipeline of products coming along.
The microbiome, which is known to be linked with the inflammatory process, its activation and control pathways, offers a potential route to supporting the natural immune inflammatory response within products such as sunscreens. In February 2019, the US FDA issued guidance to remove two common ingredients from cosmetics and sunscreens (aminobenzoic acid and trolamine salicylate), and is in the process of evaluating further safety data on 12 other widely used ingredients, with many of the chemicals detected on the skin and in blood weeks after application1, 2. This has created a need within the sunscreen and cosmetics industries for more naturally derived ingredients that could support the body's immune inflammatory response to different environmental challenges.
Working with the translational dermatology team at Manchester University, SkinBioTherapeutics has already identified a number of inflammatory pathways of interest, and routes to target these pathways with microbiome-derived regulators. Subject to a positive programme outcome, the Company intends to pursue commercialisation of any identified bacterial formulations through their addition to existing third party products or the development of new products targeted at specific conditions.
Stuart Ashman, CEO of SkinBioTherapeutics, said:
"This research programme with the University of Manchester aims to widen our understanding of the role that the microbiome plays within the immune system, and how it can be used to support the body's natural immune response. Similarly to our approach with the AxisBiotix food supplement, we hope to eventually bring immune-supporting microbiome formulations to market through everyday products, such as skin lotions and creams, where we see an increasing consumer preference for natural ingredients. This is an exciting new area of research for us and has the potential to broaden our skin health pipeline further."
Prof Cath O'Neill, CSO of SkinBioTherapeutics said:
"There is now an extensive growing body of research demonstrating direct links between the microbiome and the immune system, and consequently skin health. The Company is in the middle of a food supplement study and the potential modifying effect on skin conditions, such as psoriasis. However, with this new line of research, we have the opportunity to assess the powerful effect of the microbiome on the immune system and skin health."