Member Info for beinthelead

Yes, it absolutely is. There are ways to upload info and share anonymously, if your were inclined.

Stodge - Confirmation bias kicking in I’m afraid. Unless sources are credibly declared, we’re all in the dark. It’s AS’s philosophy.

Yes. But not that the Antigen tests viewed in that visit WERE AffiDX.

Again, this isn’t an argument. But, defensively rude as usual.

Ophidian - that’s not fact. 2+2 again. Agreed; it COULD be.

This is an interesting study. A good read.

Spike vs nucleocapsid SARS-CoV-2 antigen detection: application in nasopharyngeal swab specimens

https://link.springer.com/article/10.1007/s00216-021-03298-4#ref-CR39

Key points:

“Most of the FDA-approved commercial antigen kits (12 out of 13) target the nucleocapsid (NC). This protein, enclosed within the viral lipid membrane, is one of four structural proteins encoded by the SARS-CoV-2 positive-sense RNA viral genome. On November 3, 2020, the CDC issued a lab alert, expressing concerns regarding a potential for false positive results when implementing antigen tests for rapid detection of COVID-19, especially in the community [6]. A similar warning was issued by the FDA [7]. While this might be an inherent limitation of antibody-based tests, it could possibly be mitigated by targeting a different antigen. One such potential target is the spike protein (S).”

“The nucleocapsid, as well as open reading frames 3a and 8, is implicated as having roles in virulence, transmission, and pathogenicity [38] and is therefore as likely to undergo mutations as the spike protein despite not being presented on the virus surface. We therefore propose that for SARS-CoV-2 detection, both antigens will be used simultaneously or consecutively as was also suggested by others [39]. The combination of both antigens on the same device might strengthen the reliability of the observed result.”

As a reminder, I always found this rather straightforward and novel wording from Vatic.

“ The real game changer though is how it works. Unlike all other antigen rapid tests, the Know Now Antigen Test detects the Spike protein (not the nucleocapsid protein), which is only available on live virus, so will therefore only show a positive result for true LIVE INFECTION.”

Their saliva KnowNow test is the only other prominent antigen test that detects the spike.

We did not pass PD because the validation criteria is not aligned with our test design.

Relationships will be fine by the way. Its clear we think the test is worth validation based on the September submission and fee paid. They’d not try if discussions hadn’t lent themselves to a successful outcome.

Thanks. Very odd.

Please could you attach your reference.

Frustrating. Silly, in my view yes. But then again, I’d have had their insight in July, I’d be a lot richer today.

I’m looking forward for the days when the politics and cat and mouse is over. It’s becoming a pantomime.

Ophidian’s used his basic maths (from school). I’m not arguing.

Praise be. Cheers.

Ophidian - this sounds factual. Have you a source?

I’m surprised and elated by this. Shows we’re on the ball and the test was mature enough to submit back in sept.

AS’s glowing assessment of Medusa’s handling of the tech, plus this early submission, leads me to believe HUA was submitted months ago. Months before September.

Cheers Bella. Not sure - I’m full of green today.

RNS Today:

They had until yesterday to be added to the list, after 2 months of waiting. They then issued today once that deadline had expired. We now wait patiently (frustrated).

Study Tweet:

The study was released over the weekend and they linked to it yesterday, seemingly proud of the findings. They either tweeted it yesterday, or not at all. Would have been weird (having been a co author) retweeting it in 6 weeks time.

Might be boring, but those are two plausible explanations that challenge your conspiracy. The true story is always very simple and boring. Yours is more interesting, I must admit :).

Genuinely don’t mean to be rude - do you honestly believe that? It’s pretty tragic if so.

Energy- Why do you mean? This confirms they do RNS when they sensitive info?

Because they could have been told yesterday?????

Templar - agree mate. It’s mega frustrating. I had the same gripe when we told AVA would drive the SP. p1ss take really.

Hey, ho. I remain confident in the LFT, and actually buoyed with the RNS to say we’ve submitted and paid the fee for review. Hence we’re confident it could pass. Makes a change being on time for once.