Member Info for AndytheMKDon

Can only buy 100K shares at 1.88p before it goes to NT. Can sell 1M or more shares at 1.84 with a fixed price, no NT.

Good stuff on Tyk2 again today and we know we're in the hot spot, come on Tim lets gets the final tests and PoC completed for 1801 and head for the clinic. Else-wise lets get this licensed or sold so that someone with some gelt can get the party started. Gla. Andy. :+)

Interesting to note the mm used an uncrossing trade as the last trade of the day to push the price down to 1.81p.. Now why would they be looking to keep the price down?? No doubt there will be late trades show up in the next hour or so..

Filtered.. !! Thick as well as simple..

Unite.. Don't be so simple, your comment is like saying we have an antibiotic and some others do to, for sure you will know there are hundreds of antibiotics for different infections, it's the same with TYK2 Jak inhibitors where there are hundreds of indications we can target to treat, it's not a one size fits all..

Autoimmune contender

Sareum’s novel dual tyrosine kinase 2 (TYK2) and Janus kinase 1 (JAK1) inhibitor (SDC-1801) is a potential autoimmune therapy. TYK2 and JAK (1, 2 and 3) control cell responses to various potent messenger proteins such as interleukins. The dual kinase approach may give SDC-1801 a broad range of potential indications. The leading direct competitor is a highly specific TYK2 inhibitor, deucravacitinib, from BMS. In Q420 this met its primary endpoints in a Phase III. A second Phase III reports in Q121 and may be marketed from 2022. Pfizer has both TYK2 and TYK2/JAK1 inhibitors in Phase II but is focused on a Phase III JAK3 inhibitor for alopecia. The psoriasis market is large, as shown by Otezla (Amgen), a phosphodiesterase 4 inhibitor that gained 9M20 sales of $1.6bn after being acquired in late 2019 for $13.4bn. There are already three other JAK inhibitors approved for rheumatoid arthritis, baricitinib, tofacitinib and upadacitinib.

These guys need to understand that when CFD's go wrong they go spectacularly wrong!! They had a couple of free hits here recently with the not so great news from Aurora (it was a shelved product anyway) but as they always say in cricket there's a ball with your name on it. Specco and the boys would do well to be cautious betting against a pharma stock in the current climate, especially one being backed by UKRI ( Government ) to come up with a therapeutic solution to the cytokine storm, if they spent five minutes watching the news and not posting tosh on here, they would see the government boffs are now mentioning therapeutics within every daily bulletin.. gla. Andy. :+)

The takeaway for me from the presentation was the emphasis on Tyk2 development for Covid, link that with the news earlier of government looking towards therapeutics as effective treatments and it wouldn't surprise me to see further grants from UKRI and maybe a fast-track for SDC1801 in Covid, it seemed to be the only time he lit up in the presentation when he mentioned it. GLA. Andy. :+)

I have to say from experience that Fadec is one of the most balanced posters here and his knowledge of the science is second to none. Keep it up Fadec. Gla. Andy. :+)

Tom. I thought we’d stopped genetically modifying cabbages, you must have slipped the net. !!

Wouldn’t want to be out of this over the weekend.
;+(@). Gla. Andy.

Hello ArticFox. For sure there will be delayed trades (buys) my guess would be they'll be around 2.25p ish as the mm sat on the ask all day at 2.30 and never raised the bid to 2.20 which is where it should have been.. Lets see.. ;+) gla. Andy.

2.18p to sell and they'll take them in batches of 1M with a fixed price.
2.27p to buy and can only buy in 100K batches with a fixed price after that it's NT.
So it's clear the mm's are after shares for orders.
Gla. Andy.

Tom, you in the filter bin buddy, you are either very antagonistic or bit dolly dimple probably both I would guess..

Tom.. You're showing your immaturity, if you've ever been in a share that is suspended you'll $h!t yourself as there's nothing you can do.. I've been in some suspended shares and it's horrible waiting for an outcome believe me..

We never never ever want 4pm RNS's..
Everyone knows 4PM RNS's on a Friday are always bad news.. !!!!
Thought you would have learn't a lesson last Friday.. :+(0)

Jeez, where do they come from?? Filter box almost full.. :+0(

In a way I'm hoping 737 is brought back in house, as per Flt3, as it would make Sar a nice neat package for takeover, and yes I know CRT / CPF own 76% of 737 but they would't stand in the way if 737 was going to a major pharma. Alternatively we sell our interests in 737 and focus on the big prize of Tyk2.. gla. Andy.

Hey Mafuta. Cut Tom a bit of slack, we all had to go through a learning curve, I can remember well having to ask questions when I first invested. :+))

Scoopy / Tomfs. It’s nothing to do with imminent news. It’s purely the automated trading system unable to match trades due to the percentage variance of the trade. Just google it up it’s all there. :+)

As you say it looks like opening around 1.90.