Footsie is sitting just above the zero mark, with drug group Shire given a boost by some positive regulatory news.Shire is one of the top risers after it announced that the US Food and Drug Administration (FDA) has affirmed its prior decision to grant five-year New Chemical Entity (NCE) exclusivity to lisdexamfetamine dimesylate, currently marketed by Shire US for the treatment of attention-deficit hyperactivity disorder (ADHD) under the name VYVANSE.In the FTSE 250, McBride, which makes personal care and household products for supermarkets to sell under their own name, has jumped ahead after it said revenues in the period between 1 July and 25 October rose by 7% rise from the same period the previous year as shoppers continued looking for higher value.Galliford Try the construction and housebuilding group, has won a contract for a road improvement scheme in Scotland. The company won the £31.5m contract to construct a new 5km section of the A96 to bypass the villages of Fochabers and Mossfodloch. Bookmaker Ladbrokes said it received a 95% acceptance rate for its recent rights issue.Pawnbroker H&T Group said it has been trading well ahead of expectations for the current year due to higher gold purchasing volumes.Video equipment group Scotty reported higher half year profits and revenues and said it is confident it can grow the group despite the uncertain economic climate.FTSE 100 - RisersHammerson (HMSO) 433.00p +2.46%Shire Plc (SHP) 1,060.00p +2.42%Cable & Wireless (CW.) 144.20p +2.27%SEGRO (SGRO) 382.50p +1.89%Bunzl (BNZL) 662.00p +1.61%Reckitt Benckiser Group (RB.) 3,112.00p +1.50%AstraZeneca (AZN) 2,808.00p +1.41%Standard Chartered (STAN) 1,624.50p +1.21%Tullow Oil (TLW) 1,276.00p +1.19%London Stock Exchange Group (LSE) 890.00p +1.14%FTSE 100 - FallersLloyds Banking Group (LLOY) 92.16p -4.23%British Airways (BAY) 201.50p -3.96%Royal Bank of Scotland Group (RBS) 45.53p -3.28%Amec (AMEC) 848.00p -1.85%Eurasian Natural Resources (ENRC) 929.00p -1.64%Barclays (BARC) 356.10p -1.48%ICAP (IAP) 447.90p -1.45%Home Retail Group (HOME) 301.20p -1.44%Autonomy Corporation (AU.) 1,425.00p -1.32%Kingfisher (KGF) 233.30p -1.27%FTSE 250 - RisersMcbride (MCB) 224.20p +11.71%Bodycote (BOY) 168.00p +4.35%Kier Group (KIE) 1,023.00p +4.18%Salamander Energy (SMDR) 264.70p +4.05%Imagination Technologies (IMG) 221.00p +3.90%Dechra Pharmaceuticals (DPH) 440.80p +3.01%F&C Commercial Property Trust (FCPT) 87.45p +2.88%Davis Service Group (DVSG) 429.80p +2.58%Aquarius Platinum Ltd. (AQP) 299.90p +2.29%SThree (STHR) 273.90p +2.13%FTSE 250 - FallersYell Group (YELL) 55.90p -3.54%Hunting (HTG) 557.00p -3.21%Paragon Group Of Companies (PAG) 157.20p -2.90%Enterprise Inns (ETI) 134.40p -2.82%Tullett Prebon (TLPR) 396.80p -2.70%Lamprell (LAM) 217.20p -2.60%Shanks Group (SKS) 93.80p -2.49%Punch Taverns (PUB) 95.30p -2.46%Charter International (CHTR) 665.00p -2.35%Galiform (GFRM) 77.95p -2.26%