* FTSE 100 up 0.2 pct at close
* Weak dollar boosts miners, energy stocks
* Norway sovereign wealth fund ruling boosts oil majors
* Shire leads FTSE 100 on FDA drug approval(Adds detail and closing prices)
By Helen Reid
LONDON, Aug 24 (Reuters) - Britain's major stock index roseon Friday, propped up by Shire and commodity sectors asinvestors digested a speech by the U.S. Fed chief and the lackof a breakthrough in U.S.-China trade talks.
After a sluggish start to the session the index climbed andended with a gain of 0.2 percent at 7,577.49 points, with Shireand Antofagasta among the top gainers.
The FTSE inched to a 0.3 percent weekly rise in a week theBritish government set out plans for a possible no-deal Brexitand as sterling hovered near 11-month lows against the euro.
Trade war was still front and centre of investors' mindsafter inconclusive talks between U.S. and Chinese officials, andfocus turned to a speech by Federal Reserve Chairman JeromePowell at Jackson Hole at which Powell reaffirmed rate-hikepolicy.
Powell's comments weighed on the dollar, which in turnboosted commodity prices.
Among miners, Antofagasta shares were also buoyed3.6 percent after RBC upgraded it to "outperform", and as Londoncopper prices recovered, with the metal on course for its bestweek in four.
"We expect the shares to regain a premium valuation over thecoming months possibly enhanced by its copper exposure, whichhas significantly underperformed iron ore by 10 percentyear-to-date," wrote RBC analysts.
Oil majors Royal Dutch Shell and BP bothgained around 1 percent after a Norwegian government-appointedcommission ruled Norway's sovereign wealth fund should stayinvested in energy stocks.
Shire shares were up 2 percent after the U.S. Foodand Drug Administration approved a first-of-its-kind drug,Takhzyro, to treat patients suffering from a rare hereditarydisease.
The approval was largely expected, according to UBS, but arelief for the market which perceived the drug as very importantfor Shire's potential acquisition by Takeda.
"With this morning's announcement from Shire, the nervesshould evaporate." they wrote.
Housebuilders Persimmon, Berkeley, BarrattDevelopment and Taylor Wimpey were among theworst-performing after data showed mortgage approvals fell inJuly despite appetite for remortgaging ahead of an expected Bankof England rate rise.
On the FTSE 250, travel operator On The Beachwas the top gainer after Berenberg upped its pricetarget on the stock, praising its model of not speculativelypre-buying hotel beds or plane seats.
"In a weaker demand environment OTB 1) is not burdened withdistressed inventory being sold at a loss; 2) has low fixedoverheads; and 3) sees its main cost, online marketing,automatically fall," wrote Berenberg analysts.
(Reporting by Helen Reid and Kit Rees; editing by Andrew Roche)