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It’s interesting that when you look at the actual facts the fantasy argument that we should have known why are trial would fail has little basis in reality.
What are the facts about this so called botched trial.
In July of 2020 the company issued a statment Saying it was in discussions with regulators on the trial, so clearly they’d already started the design.
So what should we have known about impacts to the trial.
Dexamethasone NHS authorises in June following release of data. But of course that’s only 4 weeks before our trial work. The USA didn’t authorise the drug until August and the European Union not until Sept. So we could hardly have known the impact in July. Remember the results?
Reduces death by 1/3 but of course that was only in ventilated patients. In oxygen patients it was only 1/5th and in none oxygen it made no difference.
So what about the vaccines. Well the first patient vaccine wasn’t given until December so when we were working on our trial in July we couldn’t have known how effective it might be.
Off course the biggest two differences were the vaccine and the milder variants. So when we were desirous trial against Delta what did we know about variants?
The first variant Alpha wasn’t reported until December long after we’d been working on our trial.
Monoclonals were late to the game in Aug, Nov except for Remdesivir which the WHO said showed no statistical evidence of treating COVID. But even taking their own figures Remdesivir reduced hospital recovery from 15d with SOC to 11 days. Our Sprinter results we 8d so much better in retrospect.
So when you dissect all the fantasy nonsense from the likes of DocD about everything that’s been known for years. The timeframes just don’t add up. We designed a trial with the best knowledge we could not possibly knowing vaccines and variants would change the landscape of achieving our primary goal.
It’s an annoying reality that trials fail and people like to blame someone.
Maybe I’m being naive. But I stand by the fact the drug work, we just couldn’t prove it works any better than standard treatments.
Respiratory outbreaks will happen again. As do people suffering from viral exacerbations of COPD etc. SNG is still valuable.
Myths and fantasy - and then outright lies from Tommyd
So much of this is untrue - particularly the idea that Sprinter was already set in stone by July because they had started talks with regulators then. The trial design wasn't finalized until much later in the Autumn as we know and several changes were made along the way - as reported in the Clinical Update on December 18th. There was plenty of time to take account of Dexa. The Dexa results had been known for just a month when SG016 landed - but it was immediately EUA'd in the UK and the data from the 6000 patient RECOVERY was accepted immediately both in the UK and US. There was no doubt that it would save lives in the very population Sprinter was testing. 20% for people on O2 which was exactly the target population for Sprinter.
" The USA didn’t authorise the drug until August " WRONG There was no need for an EUA in the States as it was already approved, and it was in hospital use immediately in both countries before even the preprint was issued.
Reuters June 19th 2020 https://www.reuters.com/article/idUSKBN23Q2W3/
"So we could hardly have known the impact in July" GARBAGE To suggest that they couldn't know what effect it would have is utter nonsense. The entire medical establishment believed that the 6.5k trial of which 2.1k received Dexamethasone would produce exactly the same results in real world settings. That's how medical trials work when they're done properly and that's why the NHS EUA'd it instantly and hospitals in the States started using it. By the end of 2020 - and before the gun fired on Sprinter, Dexa had saved half a million lives.
"In oxygen patients it was only 1/5th and in none oxygen it made no difference. " ONLY 20% !! The Sprinter inclusion criteria was for patients receiving oxygen. 20% is a huge percentage in our exact patient cohort.
Too nice a day to waste further on your ridiculous narrative - but when you go on to suggest that they couldn't have known what effect vaccines would have it becomes surreal. 23 in trials globally by the summer of 2020 , but yeah they might have all failed or offered minor levels of protection.
You pontificate on here and throw around your pseudo science accusations, but your research is one sided and you promote a false revisionist narrative. RM began this untruth himself in the topline announcement issued on Feb 21st 2020, when he said " SNG001 has been administered to hospitalised patients on top of standard of care which changed substantially between our Phase 2 and Phase 3 trials. " and that was disingenuous in the extreme. They just weren't worried about Dexa or Vaxes even though the impact of both was clearly going to be significant.
We all know the mistakes and oversights made in Sprinter's design were colossal. Ask whoever sends you your material to try harder
All these big pharmas with their know-it-all never fail management teams, world-beating scientific expertise, colossal budgets, innovative platforms and unparalleled political clout...and yet these crackers are littering my inbox!?
"Bristol Myers reveals trial failure"
"Another attempt at improving upon AstraZeneca’s Imfinzi in stage 3, unresectable non-small cell lung cancer (NSCLC) has gone up in flames."
"AstraZeneca’s Evusheld fails to improve Covid outcomes in Phase III trial"
"AstraZeneca's drug suffered a pair of late-stage trial failures "
"Bayer's blood thinner fails Eliquis test, sinking phase 3 trial and denting $5B sales forecast"
"Merck KGaA's BTK drug flunks pivotal multiple sclerosis trials, sending shockwaves through the sector."
"Bayer to withdraw follicular lymphoma therapy after trial failure"
"Sanofi to end tusamitamab ravtansine development after trial failure"
"GSK's blood cancer drug fails"
"Pfizer, J&J scrap Alzheimer's studies as drug fails"
"Coronavirus drug remdesivir 'fails first trial'
We can all read the headlines and they don't lie; BP is as constrained as we are. Your jolly hockey sticks comparison of "little twee inept Synairgen can't compete with Big Mighty pharma", is silly and it's fast becoming a bit of a joke DocDan, as are you.
When you consider NIH didn’t call a halt to the Active2 trial until March 2022 because they felt the impact of vaccines and variants made it unlikely they’d achieve a result.
But to listen to our famous pseudoscientist Synairgen should have known all this almost 2 years before NIH realised and at the very start of the pandemic when vaccines and variants didn’t exist.
Its complete and utter nonsense, it doesn’t match the timeframes and its by someone who barely has a grasp of the science but thinks he knows better than BP, scientists and regulators.
I think he spends to much time in his basement polishing his imaginary Nobel prize
Tommyd posted the historical "truth" of the Sprinter trial and timeline of dexa and vaxes but it was fake and deliberately misleading. I corrected some of the false narrative inaccuracies. My correctional post was well researched and accurate. He said they had no way of knowing whether Dexa would have an effect even though it was trialed and approved and already in use in the UK and US before SG016 even finished. He said Dexa wasn't approved in the US, but it was already in use and didn't need to be given further authorisation. They knew for absolute certain an extra 20% of patients on oxygen would be saved but took no notice even though Sprinter's trialists were recruited using exactly this criteria. Tommy also said that they there was no way of knowing whether vaccines would affect the trial - and that was just plain stupid. Even if it wasn't until late 2020 that the data came through it was always incredibly likely that AZ's tried and tested adenovirus would be very effective - without even considering the promise of the new mRNA vaxes.
Hopefully one day SNG will find its place, but we know Synairgen wasted the generational opportunity of Covid and the huge sum of money raised to see it through to authorisation in a poorly designed P3 - as they've admitted themselves, and are now scratching around to find ways of getting the project finished with almost no money left.
Trials do fail of course - but rarely with this level of incompetence.
Yawn. Move on DocDan. You’ll wear out the Olivetti ribbon.