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Announcement that Novo Nordisk is buying DRNA at an 80% premium, so other RNAi plays (ALNY, ARWR, SLN) rise based on a view that they might also be in Big Pharma's sights. Also, likely to be some DRNA holders taking profits and reinvesting elsewhere in RNAi because they like the space.
https://investors.dicerna.com/news-releases/news-release-details/novo-nordisk-acquire-dicerna
It did rise by 9% a few weeks ago and like today, it didn`t hold up but still a good rise.
What's going on here today then? Shame they are moving to the Nas...
As far as I remember and I may have it wrong but my shares in another company that went over to the NAS, couldn`t be held in an ISA but come next week I will check with Barclays. Still looks very promising with that sort of level of investment, so still hopeful. GLA
The reason for the move up now known.
Mind, moving to the Nas only from here could be complex for some holders. I don't have an ISA
From Adfn bb
No advice intended but my understanding is that the SIPP rules (AJ Bell and Interactive Investor) are down to provider policy. HL as far as I can see is prepared to let you buy and sell in the SIPP post-delisting. The issue AJ Bell refer to and (as I understand it) the reason ADS's can't be held in an ISA post-delisting is that the ADS's are not "shares", they are effectively derivatives with the underlying investment being the Silence ordinary shares, which will be unlisted. It seems crazy (to me) given the Nasdaq listing for the ADS's - surely an unintended consequence? Today has been somewhat frustrating for me. HL came out with their instructions last night and they confirmed that they couldn't be held in an ISA. I expected a bit of a dive in the shareprice, the same as happened after the II instructions, and was ready to buy more. And there seems to have been a steady stream of sells, but today they seem to be almost exclusively AT trades rather than the O trades I would expect from HL clients selling up. And the price has held up very impressively so far.
Last post: Hawkander, 3 Nov 2021 20:54
Some good movement here today on relatively small volume, was up over 9% for awhile, interesting times ahead hopefully. GLA
Started: Alwaysone, 13 Oct 2021 20:04
Last post: Alwaysone, 13 Oct 2021 20:04
Little surpised that nobody posted this from the Evening Standard two weeks ago, but it is a very quiet board!
https://www.standard.co.uk/business/pharmaceuticals/silence-therapeutics-mark-rothera-interview-genetic-disease-mrna-b957141.html
Such small volume here each day, not a very wide spread either
OK, I'm in .... watch the markets soon lol
This seems a pretty good price don't you think? It looks like the trend is down though....ponder on buying now
Because it's an early-stage biotech in an exciting area with some big agreements signed. Have a read of the announcements they put out on deals with Mallinckrodt and Astrazeneca, and listen to today's webcast when a recording or transcript is put up to hear discussion of the market potential for their wholly-owned cardiovascular asset SLN360.
Mallinckrodt deal:
https://silence-therapeutics.com/investors/press-releases/press-releases-details/2019/Silence-collaboration-with-Mallinckrodt/default.aspx
Astrazeneca deal:
https://silence-therapeutics.com/investors/press-releases/press-releases-details/2020/Collaboration-with-AstraZeneca/default.aspx
Link to today's webcast and slide deck:
https://silence-therapeutics.com/investors/events-presentations/default.aspx
https://www.proactiveinvestors.co.uk/companies/news/957534/silence-therapeutics-hails-first-half--marked-by-strong-execution--957534.html
£5.6 mill revenues in 6 months?
how come its got an mcap, x 100 of that
Last post: Hawkander, 11 Aug 2021 18:15
Results out tomorrow, hopefully some positive news. GLA
Up we go again I am waiting for 20 pounds
Last post: Hawkander, 19 May 2021 09:03
Just seems to be getting better and perhaps some more movement North. GLA
It's it a rise or just oscillation? Nice news this morning though!
I thought I was the only shareholder ....lol Good seeing another decent rise and with this conference coming soon, maybe we will hear some positive news. GLA
Think I am the only shareholder in this company but nice to see another move up....yes it is
Started: Spks, 1 Apr 2021 18:07
Last post: WinnerTakesAll, 8 May 2021 11:19
I love SLN. I have been in for many years and with all the support from US pharmaceuticals and great technological advances up, up and away imho. GLA.
All the action with my other holdings 88e... Dev and up sneaks sln with a nice rise today....think I'll have a beer
Last post: Hawkander, 21 Feb 2021 16:38
Would be good to get some updates for going forward, after small but fairly consistent rises of recent months, the last couple have been around 5% which is a nice change. GLA
LONDON, Silence Therapeutics plc, AIM: SLN and Nasdaq: SLN ("Silence" or "the Company"), a leader in the discovery, development and delivery of novel short interfering ribonucleic acid (siRNA) therapeutics for the treatment of diseases with significant unmet medical need, today announced that its President and Chief Executive Officer, Mark Rothera, will present a company update at the virtual 2021 SVB Leerink Global Healthcare Conference on Friday, February 26th at 9:20 a.m. EST / 14:20 GMT.
A live webcast of the presentation can be accessed via the Investors section of the Company's website at www.silence-therapeucs.com. An archived replay of the webcast will be available on the Company's website following the conference.
Hopefully some good news updates
Started: Rykan, 9 Feb 2021 16:26
Last post: Rykan, 9 Feb 2021 16:26
I haven’t posted here in a while... but it looks like the new CEO and company is still ticking of the to do list. Quite a few things on the old list are now completed. The new guy in charge with this asset raise, has plenty of levers to pull imho. Likely he will push the GOLD platform and accelerate proprietary assets and SLN124/360 - but equally could announce a deal with takeda in coming weeks/months. Plenty of news items he can create to keep the shares here bid. Despite the covid interruption amazingly this company has barely missed a beat following the ARWR playbook. I expect the new CEO to continue that effort - the current asset raise reinforces my belief in the new CEO and the company.
My list looks something like - input always welcome
* Quark results as always delayed... Q1
* Takeda transition to an actual deal Q2
* Sln124 results Q2
* SLN124/360 results 2H
* Announce other proprietary assets Q2
* possibly another pay to play deal like Takeda 2H
* Probably a collaboration deal with E-Therapeutics 2H 21
* Results of Novartis Inclisran Phase 3 data 21
* Possible takeover of ARWR at a premium. 21
* MNK making another milestone payment 21
* Deal for SLN360 22
* List in the US Sep DONE
* New CEO end of Q3v DONE
* File IND for SLN360 Q4 DONE
* Strategic biotech investors DONE
*Mnk bankruptcy DONE
* MNK executing other options on 2 complement assets DONE
think this will move up again now americans love these type of investments
Love this share as it is a nice type of business rather than drilling for oil?? owes me nothing as I sold some and hold profit as well as remaining holding be nice to see 20 pounds plus
Started: WinnerTakesAll, 27 Jan 2021 08:50
Last post: Hawkander, 27 Jan 2021 10:40
I hope your excitement lasts and it continues to grow, we are almost at the 52 wk high and it`s been a few % up each day for quite awhile now, so hopefully something is happening in the background. GLA and stay safe.
Further to my message on 1st Jan 2021 I am excited about how far this can go. GLA.
Last post: Hawkander, 21 Jan 2021 12:17
Are we expecting news, as SP has held around this area for what seems a lifetime and today we are up over 5% which is an unusual rise for SLN?
Last post: Hawkander, 8 Jan 2021 13:53
Interesting rise, maybe the fireside chats next week will be positive news. GLA
Started: WinnerTakesAll, 1 Jan 2021 11:02
Last post: WinnerTakesAll, 1 Jan 2021 11:02
Sold the lions share of this at £4.30 a couple of months ago. Bought in a few weeks ago at £4.00 with my Sipp and with RNA technology being in focus with the vaccines I hope that this share can continue its journey north in 2021.
Last post: Snowdrops, 14 Dec 2020 15:41
of £946k each...I guess someone had enough.
Yes the price is up..
Started: Marcusp, 8 Dec 2020 17:36
Last post: Snowdrops, 10 Dec 2020 11:51
I hope so. This share seemed to take north before Nasdaq listing but in the absence of any substantial news it went the wrong direction afterwards. I would think that new CFO based in US would be announced by January and hopefully that will push the price up. Small trading volume seems to swing the price quite a lot here.
Is my favourite share about to take off again?
Started: ShareSocUK, 17 Nov 2020 12:36
Last post: ShareSocUK, 17 Nov 2020 12:36
The presentation packs and recording from our webinar with Silence Therapeutics on 11th Nov can be found here for full members to view: https://www.sharesoc.org/seminar/sharesoc-webinar-with-silence-therapeutics-sln-11-november-2020/
To access the presentation, you'll need to be a full member of ShareSoc, which is a not-for-profit organisation that supports individual shareholders and campaigns for shareholder rights. If you're not already a member you can join here: https://www.sharesoc.org/membership/
Once you've joined, you'll receive an invitation to register for our "members network" private social network, from where you'll be able to access the presentation (and presentations on 100s of other meetings). If you're already a member and have any difficulty accessing the report, please do not hesitate to contact us here: https://www.sharesoc.org/contact-us/
Started: sarahrodz, 16 Nov 2020 09:56
Last post: sarahrodz, 16 Nov 2020 09:56
These results give us confidence to move SLN360 into the clinic, to develop a transformational medicine for the millions of people facing a higher risk of cardiovascular disease due to elevated Lp(a).
Last post: Agentmahone, 11 Nov 2020 08:49
Although not directly related, I expect the Pfizer vaccine news hasn't hurt...
That`s a big rise for us and 2 hefty sells/buys at over 400k after 4pm, are we expecting some good news?
Just wish the institutionals would see what a good move that is and get in on the act.
Started: Suckitup, 14 Sep 2020 08:50
Last post: Suckitup, 14 Sep 2020 08:50
2 very positive RNSs this morning re: financials and the appointment of a new permanent CEO with lots of very relevant experience in terms of the product and the business/operations of dual listing and growth. Well done.