The latest Investing Matters Podcast episode with London Stock Exchange Group's Chris Mayo has just been released. Listen here.
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Yes keeping an eye on that sale, no whispers found anywhere of who could be buying DoseMeRX.
And for clarity and so no mis-information can be spread, probably Monday, there will will 2 x 90k ish trades go thru very close together. They will look like sells, they are indeed my B&I which will be added to my pot of over 900k shares, just in case any of the usual protagonists mis -read the trade data & try and spin it a different way.
There was a signed letter of intent for the sale but looks like it's still under some NDA...
Kiddlington Worth keeping tabs on this sale?
Q: The tie-up with Tabula Rasa and their DosemeRx platform was considered to be a potential game changer for Physiomics. Now that Tabula Rasa have advised the market that they are selling their interest in DosemeRx does this in any way diminish this commercial potential
The answer to this was also covered during the main presentation however just to say that DoseMeRx remains interested in working with Physiomics and we are actively looking at other opportunities to commercialise our personalised dosing tool and platform. Physiomics has no knowledge of who might be interested in buying DoseMeRx but believes there is a reasonable chance that whoever it is, is going to be at least as interested in personalised dosing as DoseMeRx’s current owner.
This buy out is currently going on and once new buyer comes then PYC will be able to agree commercial terms with new purchaser
*2021 sorry lol
Clients results for second quarter:
https://www.merck.com/stories/our-second-quarter-2021-financial-results/
Merck announced second-quarter 2021 sales from continuing operations (excluding Organon) of $11.4 billion, 22% above second-quarter 2020. Excluding the impact from foreign exchange, sales grew 19%.
https://investors.bicycletherapeutics.com/news-releases/news-release-details/bicycle-therapeutics-reports-second-quarter-2021-
Collaboration revenues 6 months ended June 30
2020: $2,700
2021: $3,593
https://www.lse.co.uk/rns/PYC/final-results-setufg8l0ipbdl4.html
Total income (revenue and grant income) decreased 13% to £730,899 (2020: £841,649), the third highest in the Company's history despite a full year of the impact of Covid-19
Snippet from 2031 results….
the Company has been able to:
· Support big pharma companies in developing evidence based dose reduction algorithms to optimise the balance of efficacy and toxicity. These algorithms have the potential to be used in the pivotal studies of significant big pharma pipeline drugs
· Predict the clinical efficacy of cancer regimens amongst patients with various specific genetic settings, based on extensive preclinical modelling and then translation of these settings to man
· Use modelling to generate hypotheses as to the mechanism of action of client assets and predict/ explain why they may have a competitive advantage over other marketed drugs with the same targets
· Support and inform first in man dosing based on predictions of biologically effective dose from computer models
after yesterdays announcement by Sareum: https://www.investegate.co.uk/sareum-holdings-plc--sar-/rns/sareum-notes-acquisition-of-sierra-oncology-by-gsk/202204131600173162I/ There is a historical link between PYC business and SAR https://www.physiomics.co.uk/company-update/ dated (Dec 2016) https://www.physiomics.co.uk/wp-content/uploads/2019/04/2017-1-11-Company-Update-2.pdf
The work was done is association with CRT and ProNAi, who then changed their name to Sierra. https://www.prnewswire.com/news-releases/pronai-relaunched-as-sierra-oncology-to-advance-ddr-based-cancer-drugs-610090235.html Drug was called PNT737, then to SRA737
Well it all sounds good, a strong pipeline, but the interim results also showed the operating expenses have increased so firstly what did it cost them to get that pipeline, and secondly can they sustain it, because they haven't been particularly consistent.
The £1mln raised May 2020 remained almost untouched UNTIl they decided to spend for EXPANSION of staff and MARKETING etc
The increased cash was 3+ new staff and increased marketing!
I.e PLANNED spending !!
Q: Please say a few words on the current pipeline?
The pipeline is genuinely the strongest it’s ever been. For the first time, we’ve really been able to quantify that by disclosing that we have contracted revenue of over £460,000 for this half that we’re in now. We’ve never been able to say that before. We’ve never had that degree of visibility for the next five months. And obviously that’s just the revenues that we have signed up at this point in time.
Above these contracted revenues in the pyramid of Business Development we have a number of contracts that are in discussion, one of which is with another big pharma Company. If we can clinch that one, that is another very exciting opportunity and could be a big step forward for the Company. But it’s not the only opportunity. We now have a more rigorous process for categorising the different opportunities thanks to our new BD lead. While this isn’t something that I can explain in a few words, I can assure you that at every stage within that BD funnel we now looking stronger than I think we ever have done before.
Cash and cash equivalents of £794k at 31 December 2021 (31 December 2020: £1.15m)
356k decrease in cash in 1 year.
annual net cash outflow a mere £34k for this last year
Total income was the highest first half income ever recorded by Physiomics and slightly ahead of the six-month comparable prior period ended 31 December 2020. Operating losses of £170k were just £38k greater than those of the comparable prior period despite a significant increase in marketing activities, including the hiring of the Company's first Head of Business Development. The Company finished the half with a strong balance sheet showing shareholder funds of £1.08m at 31 December 2021 (compared with £1.29m at 31 December 2020) of which £794k were cash and cash equivalents
https://www.investegate.co.uk/sareum-holdings-plc--sar-/rns/sareum-notes-acquisition-of-sierra-oncology-by-gsk/202204131600173162I/ RNS just landed… interesting we had involvement in this?
I like this snippet
In addition to the areas noted above, the Company is actively considering how it could use its extensive capabilities in modelling, simulation, data analysis and AI techniques, to develop further innovative assets in collaboration with other partners. The Company is particularly focused on fields such as AI-enabled drug discovery/development and cancer diagnostics. Further information on this initiative will be provided as progress is made.
Q: Can we say how long we’ve been in discussion with the potential new big pharmaceutical client?
We’ve been in discussion with them for over 12 months, and that is common for big pharma clients.
Large pharma been in discussions 12 months prior to March 2022 interims news due
From the interims.. In addition to the areas noted above, the Company is actively considering how it could use its extensive capabilities in modelling, simulation, data analysis and AI techniques, to develop further innovative assets in collaboration with other partners. The Company is particularly focused on fields such as AI-enabled drug discovery/development and cancer diagnostics. Further information on this initiative will be provided as progress is made.
It won't take a lot too move this up nicely!
Another £1600 in JISA
£5k is 5p
£2.5k 4.8p
£15k 5.2p