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Raising awareness of sng home and other potential trials as mentioned here is also a good idea in general. Though I'm not sure what would be the "action" for the MP, I seriously doubt they would go-ahead and ecourage people to enter specific trials.
Thanks for sharing the letter
1. Technically this is not a natural product, this is a recombinant version of the human protein (all very standard). A natural product is something that is isolated from a plant for example and without any further modifications. Consider "this protein is naturally used by our bodies to protect againsnt viral infections"
2. I would not make assumptions on where the drug would work. Though dexamethasone has shown good results, the population to which is addressed is by no means fully served and the two drugs are not necessarily mutually exclusive (probably not at all). I would very briefly describe the drug (make sure you describe that it comes as an injection that can be loaded by the patient into a nebuliser to deliver a drug). Then in two lines the main results from the trial (with a link from sng website NOT an LSE link :) ) and then refer to the excellent presentation by Dr Campbell that was posted here before https://youtu.be/PWCjj34j_Rg He is a known and trustworthy name/face and the video explains really well the basics as well as the results of the trial so far (though it could be a bit shorter). This will also make the letter shorter (consider also removing some other stuff if you want to keep it more focused). In general avoid investor websites, the description of the trial results should come from SYN website, video from Dr Campbell if you want, and perhaps a news item/press release from a UK University/NHS
3. I wouldn't mention so much early approval or anything like that (that's the job of the regulators and an MP cannot and should not interefere in that particular issue so this is non-actionable to them). Describe instead a picture of what would happen if sng confirms good results but they don't have any drug available for use outside trials. In this case perhaps you can move the interview link you have to this section (though from proactive investors it raises a specific issue that is not raised elsewhere) to emphasise that the company is actively looking for help from multiple governments (as mentioned in video) to actually make the drug. I would ask specifically how is the UK making sure that if results are confirmed, the drug will be immediatelly available for those who need it. This is something MPs *could* act upon by asking the same question to relevant departments.
4. Maybe try to emphasise that is UK developed, perhaps throw some brexit in the mix and the need support UK cos if you are feeling cheeky :)
Anyone who wants to can write to their MP about anything they like.
The idea that there is no political element to the biggest problem of our times is daft.
Government is throwing our money at big pharma like nobody's business.
The only benefit I can see to lobbying MP's would be to get them to raise the profile of the home trial so it could be filled faster. It's probably a little late though. The government would have been well aware of it when that arm started back in May. Han**** neglected to mention the home trial arm when he spoke of the hospital trial readout in parliament. I was shocked as that was a perfect opportunity to help.
Having said all that, the lack of government involvement or help over the last 6 months means they can hardly expect any favours when it comes to paying for SNG001.
Looks like a unanimous decision.
Bad idea to contact your local MP
Page 3 draft 2
We don’t have that much time and if we are to prevent a further massive death toll I would ask you please to consider putting pressure on the Health Secretary, the government and PHE to allow this drug to be used experimentally in the NHS system obviously with detailed checks on each patient so that further clinical information can be obtained in real time under emergency procedures. This process could form part of a Phase III trial. Also government funding should be given to enable any procedural hurdles to be overcome quickly and set a wartime equivalent footing for production and distribution in the expectation of a huge take-up requirement throughout the nation by hospital doctors, GPs and infected people in ‘at risk’ categories when the treatment receives approval. This is a massive opportunity for us (both the UK and the rest of the world) to come through the pandemic whilst minimising serious illness and death, hopefully avoiding a second lockdown whilst keeping the NHS functioning all at minimum cost.
This is a link to an interview given by Richard Marsden CEO of Synairgen Plc on 8th September 2020 which you may find helpful.
Your help would be beneficial to advertise the availability of places on the at home trials for citizens over 50yrs and/or with co-morbidities who have received a positive test and apply within seven days of symptoms appearing. http://www.covidtrialathome.com/
This drug has the potential to save countless lives and enable us to reopen our economy to the benefit of us all.
I have written this letter intending it to be an open letter and will send a copy to the Health Secretary, the Prime Minister and various media channels.
Page 2 Draft 2
Early activation of the immune system has been shown to reduce lung damage, collateral damage to other organs and also help to prevent the deadly ‘Cytokine Storm’ which has killed many.
This link gives details released July 20th 2020 of the Phase II double blinded clinical hospital based trial of 101 hospitalised Covid patients with placebo treated control of half the group. https://www.lse.co.uk/rns/SNG/positive-results-from-trial-in-covid-19-patients-fihvg7kkd3390v1.html ‘The odds of developing severe disease (e.g. requiring ventilation or resulting in death) during the treatment period (day 1 to day 16) were significantly reduced by 79% for patients receiving SNG001 compared to patients who received placebo’. I think anyone would be impressed by such a drug that would reduce the incidence of severe disease by a factor of almost five.
There is currently an extension of this trial being undertaken in the UK with at home elderly and high risk patients being sought for self- treatment of early infection. Due to lack of awareness exacerbated by the patchy testing availability and slow speed of results this has not yet been filled as far as I am aware. The expectation of scientists working on this is that this treatment, if administered pre-hospitalisation is likely to have a profound and significant effect in reducing the likelihood of hospitalisation being required. Also it would have the massively positive effects of reducing the severity of the disease and subsequent ICU requirement, intubation and death and help prevent hospitals filling up with Covid patients over the winter.
The product, by boosting the immune system will also most likely have a beneficial on influenza patients whether or not they have co-infection of Covid. SNG001 efficacy is not diminished by concurrent cortico-steroid treatment, clinical conclusions from COPD trial.
The government has spent millions on the search for a vaccine but even if discovered this will not be perfect; take-up may be low and it probably will not be in place before late 2021. Apart from availability of speedy testing which number on short term priority, the UK and the world needs an easily administered treatment that is effective in the early stages.
As you will be aware the normal validation process for a new drug or medical treatment is long-winded and expensive. The next step for SNG001 would normally be a full Phase III trial involving perhaps 1000 people. The product has been shown to be safe over many years during its use in COPD and asthma trials and is well tolerated by the body firstly because it is an innate protein and secondly because dosing by nebuliser is direct to the lungs and requires much lower dose requirement than I/V or injection which have both been tested on patients. I am not aware of any significant side effects for the inhaled version.
Thanks for the feedback particularly marlow.rupert and Sparkle1. I have made some of the suggested amendments and made some of my own alterations and have posted the revised letter below. Sorry I am too knackered to try and precis it down to one page but others can.
I also note the differing views about the use of writing to MPs and agree that probably lobbying influencers would be very useful. I will send letter by email to contact suggestions and others can write their own, nicking any bits of this they want. I have no knowledge of Twitter or any other social media so I am sure others are better placed than me in this regard. They may even know some 'influencers'. If so please do it.
I am frustrated that there has been no concentration by the government on any treatment. Only vaccines, testing and PPE.
I haven’t received a reply from my last email of 4th August to you about airport testing but no doubt you are very busy at present with current problems and planning for the severe repercussions that will be coming due to the countrywide second wave breakouts of Covid infection right now and just prior to the winter ‘flu’ season.
It is vital that we do not allow our hospitals to be overrun with Covid patients for a second time, many of whom will unfortunately and totally unnecessarily die due to lack of effective treatment. I would like to draw your attention to various links below that will help you to corroborate the contents of this letter and assist with your research into Covid-19 treatment.
There is currently only one treatment available in the UK as far as I am aware. This is Dexamethasone which I understand has been shown to have a positive effect in patients requiring oxygen and ventilated patients. https://www.gov.uk/government/news/world-first-coronavirus-treatment-approved-for-nhs-use-by-government This does not prevent serious illness since it is only effective when patients are already seriously ill and likely to have long term health implications if they survive.
Fortunately, there is a natural product that has been worked on for 15 years by a team of scientists out of Southampton University, initially to help asthmatics, subsequently COPD patients and latterly repurposed in the fight against Covid-19. This product has the unprepossessing moniker of SNG001. It is a nebulised inhaled preparation of Interferon Beta 1a. This protein is an important part of the first line of the human body’s defence mechanism. Interferons are present in the blood of healthy people but the levels of interferons reduce with age. This is the main reason why elderly people are more vulnerable to severe symptoms and death following Covid infection than younger people . Not only this, but the Covid 19 virus has been shown to prevent release of further interferons by cells that are infected with the virus. This virus therefore effectively disables the body’s first line of defence enabling its swift multiplicatio
I've been tweeting Matt Han**** almost daily for the last three months, but have been voting in the likes of Laura Spinney who wrote the good article in the Guardian about interferons recently and have also been tweeting Justin Rowlatt who did the panorama piece on SNG (although he seems to focus on climate change primarily these days).
If anyone is up for it, Geordie comedian Sarah Millican follows Synairgen on Twitter. Any fans want to ask her why she follows them and suggest she gives them some publicity?!!!
Got f*** all to do with the Daily Mail as a vehicle! Don’t shoot the messenger! Look at the substance of the story in terms of understanding big government linking with big Pharma and a centralised PHE & MHRA, and associated groupthink, so neutralising the potential impact of innovative, disruptive smaller companies with novel technologies.
Bill creates viruses do he can cure them, he done it with Microsoft.
He is not a virologist or Dr or medical scientist! He is a egotistical globalist who wants to create the ultimate legacy. Research his vaccines and disgusting treatment of third world child/experiments and then claim he's your idol. Africa and India is his playground. Why not USA?
Hold4results... Agree with you totally...just filter him... not worth your time.
@mac I'll listen to the Daily Mail talk about corruption and house prices when they do the Paul Dacre exposé, and not before
B0ll0cks to that. He was a very sharp businessman and can be fairly criticised for his business practices. He is also an amazing problem solver and since he switched focus he may have already done more to alleviate public health problems than anyone else in history.
I actually disagree... earlier in the summer, i got replies from two in houses of lords, one from ex nhs ceo, and one from someone on the Cabinet and one from the guy who is effectively the ceo of the church of england ... lobbied him to get archbishop of c on case. Watching the footie on tv but i will dig out over weekend. Think it helps if you suggest something they can do that is positive as they just get a ton of flack. Helps if the letters are a page long only and include the links they need to check it out. So instead of saying why havent you done this, Probably better to say, please can i Draw your attention to this (link) which i think will greatly help you to progress your work on covid.
I,ll send over some links over weekend..
Bill Gates is a egotistical multi billionaire business man with the desire to be the number one messiah, he is so heavily invested in vaccine he couldn't give a f*ck about sng and there successfull treatments, he'll swat you like a fly and that's the truth. All hail bill lol
Declaration of an interest? Where and when?
I admire Bill and Melinda, must give them so much satisfaction, unlike Jeff Bezos , he could do so much, makes my blood boil... sorry I know nothing to do with Synairgen, who also have contributed so much...
Say what you like about government, Bill and Melinda are tireless heroes.
This guy deserves a lot more recognition: https://www.theguardian.com/business/2020/sep/19/billionaire-chuck-feeney-achieves-goal-of-giving-away-his-fortune
I'm invested here and not selling, however I do feel the government have been bought by big pharma, WHO, bill and Melinda gates foundation. Listening to Boris speaking earlier confirmed for me they are all in bed together. "conspiracy" maybe but I'm doubting now the government want to find a treatment with so much invested in a vaccine. Shot me down, but listen to Boris speak earlier and tell me I'm wrong!
My MP is mildly scared of me and replies within hours with obsequious guff.
This isn't a normal government, remember Boris sacked all the moderates and regularly threatens withdrawing the whip.
Most of them rather like the whip.
should read " all letters from paid up members of the MP's party"
Take it from me any letters are first scrutinised by the MP's secretary first. All letters from members of the MP's constituency will be seen by the MP. Others will be passed to him/her upon the discretion of the secretary. Personally speaking unless you are known personally to the M.P it will be a waste of time.