Charles Jillings, CEO of Utilico, energized by strong economic momentum across Latin America. Watch the video here.
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I'll definitely be there.
Im coming too. I shall do some research on how to get your votes if via nominees accounts and circulate. looks like a fun day out :)
Zylo - The AGM - Its in my diary and unlike last year I'll be in the country. Going to make a day of it!!!
There’s far far worse than Utah on other sites, don’t know if you can take that as a positive Utah, not sticking up for you personally, I’ve been overly excited sometimes to reach nowhere and it’s not all plain sailing so until the time is right the doubters are in a better position than the positive people, so down the company to be able to perform, which we all can agree on is happening in the lab!
Not sure when zylo? I have consistently said I have owned and I have also traded . I have also swung from being very optimistic to being pessimistic. Regardless at present sar share is not performing well. F knows why and I think we can all agree to that? Sierra handling has been a shambles but heh all this may change and I hope it does. But to me what I may write and what someone writes about 2 pound can be pigeonholed the same- just unsubstantiated comments . So let’s just wait for the next news and go from there
Riiiiiiight
You were caught lying so many times
I tell truth and I only vaguely remember awoo. So bit confused , are we saying that all is good with sar, if so why the angst against Parker ? Really do not understand. Since if sar is all good surely non executive are doing good job?
Ahfam
Doubt anyone will go
Maybe the ones making all the noise will have the bottle to turn up , doubt it
Get ready for the excuses, got work commitments etc etc
I can't possibly comment on whether the 2 chaps/etts mentioned are the same or truthful- but there is a proverb that goes 'the punishment of a liar is that even their truth is not accepted'.
Anyhoo- AGM has been announced those going please wedgy our Parker if you get a chance or at the very least give him a nudge on boarding institutions.
Obelix and bell , you should be careful about accusing people of being bi polar. First of all I own 1.79m shares , would consider increasing if I make money out of pyc. Second it is not thought police here. I just get peethed when I read too much of stuff that contradicts what share price is doing, the fact that milestone payments have not turned up, that Sierra share price has plummeted and has had to give up a share of company to avoid paying milestones, that our share price is trading at very low level, that one day of rise and you get people who start saying it’s a 2 pound a share value and the there is a tirade of posts which read more like a plot in Agatha Christie model in terms of joint up the dots latest being that someone from suerrra is coming to uk so this must mean an explosive rns is about to happen. So sorry guys I have paid my money, I have bought shares so I can say what I like
Morning JonBell, how are you Mate? I hope you're well..
I believe you're 100% correct regards to, your post about Bipolar person.
Awoo and Utah are the same, possible could be the same person, if not I'm sure both are Bipolar and personality disorders.
Better NOT contradict them, they can turn your enemy overnight or 1 min (all depends on the mood)... lol
Have a nice day Mate, take care.
Obelix
I’m not so sure why you entertain Utah, he’s been here since his old sidekick awoo was here. He’s not invested in sar, in my opinion. One day he had 3m shares then it dropped to 1.5m and so on. It’s more difficult remembering lies than the truth. These types of people are bipolar or have some personality disorders.
Apologies if this is not true utah, I just get bored of reading your negative nothingness every time you post. Same with warthog, who cried the mms were playing games again on the sell price yesterday. Always there should be yin with yang, just why can’t the negative posters be truthful?
Concerning the tweaking, our tyk2 was also tweaked for the cell infereon, to overcome resistance, it was stated as such in an rns sometime ago. One of the reasons Sir Tim and John started this journey was through seeing molecules getting stuck in a long line with no movement unless passed off by seniors.
Anyway, it’s a nothing post really.
Love peace and harmony
I rather it be 100 times in price!
My response is. We have the patent. And until it fails it's worth 100 times the current sp.
Thoth
It would give me more confidence if we were licensed to a company who can afford to pay milestone payments rather than giving up a share of company and reduced royalties . Fine for Celgene as they can take the risk , but bad for sar considering they have there one and only licensed product with the failing company. Don’t believe srra will be announcing much in London Thursday but would love to be proved incorrect. Current situation not confident
Can’t rush it everything must be just right, Pfizer was the other one with Tyk2 and JAK1 in psoriasis but they consentrated with their JAk1 (Abrocitinib)in the same indication I haven’t heard they dropped it but consentrated with the JAK1!
Pfizer PF-841 their Tyk2/Jak1
https://server.aad.org/eposters/Submissions/getFile.aspx?id=4546&type=sub
Just Abrocitinib
https://s21.q4cdn.com/317678438/files/doc_financials/2019/q3/Q3-2019-Earnings-Charts-FINAL.pdf
https://www.pfizer.com/news/press-release/press-release-detail/pfizer_announces_positive_top_line_results_from_second_pivotal_phase_3_study_of_investigational_oral_jak1_candidate_abrocitinib_in_patients_aged_12_and_older_with_moderate_to_severe_atopic_dermatitis
Structure Activity Relationship (SAR) that what the name stands for John has worked hard in this and have had some bright minds around with the Oxazole tyrosine kinase inhibitors structures!
I haven't worked in drug development. But read a great article years ago from someone who did. R&d departments always under pressure with facilities closures and job cuts. The ceo sends the message down "I need to move 3 compounds into trials before the next annual statement". Research director thinks "these ones aren't quite ready. But my target and bonus and options depend on me shoving 3 through. I'll pick these ones that aren't ready bust the best candidates I have". I suspect there was a lot of truth in that.
We took.a decade to get chk1 in the clinic. Tweaking. The famous multiparameter optimisation paper.and are now the only chk1 left in the game. The big boys all dropped out. Perhaps in the eagerness they didn't optimise enough. On tyk2 . Bms is pure. Ours has some jak1. There are some pure jak 1 compounds in immune. So the aspiration is ours may be better. Or enable lower dosing . Galapagos tyk2 been dropped. Pfizer tyk2 is more dirty than ours which will li.it doses. Nimbus tyk2 not on celgenes website. Not mentioned on bms earnings call. Celgene is no longer doing earnings calls. It possible if I am a cynic that nimbus have been stitched up like a kipper. Celgene have exclusive rights. Bog them down in preclinical for a few years where bms races ahead. Leaving little sareum the only real competitor. There is space for multiple compounds. Each will be more suitable for different subsets/ genetics. Still think it's a blockbuster potentially. Utah. What's a 10% royalty of half the $17bn bid market ? And what's that in sp ?