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Winne has gone sheepy has gone now it’s. Touks shift
Ice
Yes of course I understand that and I wouldn’t be surprised if they move to a weekly dosing regime to keep the levels of AVA6000 as high as possible in order for as much as possible to be in bloodstream around TME. And of course it’s the precision of AVA6000 that enables this and why we are all here invested.
You do realise they can administer many cycles over the current treatment of Dox hence why we are seeing results in patients that are still on this chemo approximately a year at a lower dose of AVA6000. It’s the cumulative dose that’s important and number of cycles over the current standard toxic version of the chemo.
CTSFO
Yes if the rapid reduction in free AVA6000 is mainly due to it being cleaved in the TME then that is brilliant, but as I say based on the overall results including biopsies and what has happened to clinical trial design, then IMHO, it isn’t, it’s being excreted too quickly. Perhaps our metabolism and kidney function is far better in this respect than mice?
Dilution in terms of parts per million of AVA6000 versus blood. As uncleaved AVA6000 is excreted (or whatever the correct term is) from the body, the amount in the blood decreases. That’s what I mean by dilution. Therefore less available in TME to be cleaved.
Lovable
You are quoting dox half life. That is meaningless in my argument (other than ensuring that any cleaved dox that escapes from the TME is excreted quickly before it can do much harm to other organs). I was referring to the AVA6000 half life stated in the original article.
Oxygen
Right on and that’s why Al won’t do any deal that means he would lose control of his baby. Primarily he is in this because it’s his life’s work.
Tim
Thank god you’re still here. I was beginning to worry about you 😄
Sheepy I’m sitting on a fortune. Not long to wait now !
I have more green boxes on here than posts that I actually read . So much drivel
The ramping is not what it used be look at the tumbling share price!
Where is M Mcfarce when rampers need him?
Oh dear oh dear!!
Says Watching who boasts about being in at 68p. Think you might be a plonker too
Sheepy aka wynbore your such a plonker lol
Off to the Green room . Oh no please don’t . Please don’t I’m really sorry please don’t
Just send them to the green room...so much easier not having to read the endless BS.
You are engaging Groot by posting about it. Really bright aren’t you!
i hope episode 3 has eggy and touk from the fud department talking ****e.
Good to see there's a team actually working stuff out, and not just AS making it up as he goes along, eh Thorn?
More trolls lol who pays these muppets 🤡
The quality of the trolling and fud on this board is downright embarrassing. They can’t spell, spout barely coherent nonsense, repeat themselves constantly and generally try to obfuscate any positive attempt to have a rational debate.
Just stop engaging with them.
It was pretty basic stuff I thought, well below the level of understanding and knowledge that I thought most posters on this board operated at.
Fine for easing newbies into the concept etc but beyond that?
Could you give an explanation of why from the video you thought CC was a breath of fresh air
Now if you are developing a new drug would you look to trial that drug as it is and with a PreCision warhead. Seeing how PreCision has so far exeeded all expectations dose wise, it would certainly be a good sales point if Avacta is looking to target bothe the existing and new drug market places.
Mmm..Approval clearly shown on the chalk board after P3...
What say you question shepley£ me no understand your english
Why you say that (typo)