Notifiable Interests

20 Nov 2007 17:24

Proteome Sciences PLC ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences PLC

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Crĩdit Agricole Cheuvreux International Limited

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

16/11/07

6. Date on which issuer notified:

20/11/07

7. Threshold(s) that is/are crossed or reached:

Holding after transaction went through percentage threshold

8. Notified details:

A: Voting rights attached to shares

Class/type of Situation previous to Resulting situation after the triggering shares Triggering transaction transaction if possible Notification required under DTR transitional using ISIN provision 7 CODE Number of Shares Number of Number of Number of voting % of voting Voting shares rights rights Rights Direct Direct Indirect Direct Indirect GB0003104196 10,530,481 10,530,481 10,480,481 10,480,481 7.97% B: Financial InstrumentsResulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that may % of financial date Conversion be acquired if the instrument is voting instrument Period/ Date exercised/ converted rights Total (A+B)

Number of voting rights % of voting rights

10,480,481 7.97%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

SAS Rue La BoĩtieCrĩdit Agricole SACalyon SACrĩdit Agricole Cheuvreux SA 10,480,481 7.97% 10. Name of the Proxy holder:N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A13. Additional information:N/A14. Contact name:Karen Browne

15. Contact telephone number:

020 7214 5282