Holding(s) in Company

For filings with the FSA include the annexFor filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer Crystal Amber Fundof existing shares to which voting rights are Ltdattached:ii 2 Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights An acquisition or disposal of qualifying financial instruments which may resultin the acquisition of shares already issued to which voting rights are attached An acquisition or disposal of instruments with similar economic effect toqualifying financial instruments An event changing the breakdown of voting rights Other (please specify): Corrected, using post-placing SII number of 95,941,800 X 3. Full name of person(s) subject to the Woodford Investment Management LLPnotification obligation:iii (Woodford) 4. Full name of shareholder(s) Clients of Woodford (if different from 3.):iv 5. Date of the transaction and date onwhich the threshold is crossed or 23.1.15reached: v 6. Date on which issuer notified: 27.1.15 7. Threshold(s) that is/are crossed or 5, 10%reached: vi, vii 8. Notified details: A: Voting rights attached to shares viii, ix Class/type Situation previous Resulting situation after the triggering transactionof to the triggeringshares transaction if possible Number Number Number Number of voting % of voting rights xusing of of of shares rightsthe ISIN Shares VotingCODE Rights Direct Direct xi Indirect xii Direct Indirect GG00B1Z2SL48 0 0 9,646,302 9,646,302 10.1% B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of financial Expiration Exercise/ Number of voting % of votinginstrument date xiii Conversion Period xiv rights that may be rights acquired if the instrument is exercised/ converted. C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments xv, xvi Resulting situation after the triggering transaction Type of Exercise price Expiration Exercise/ Number of voting rights % of voting rightsfinancial date xvii Conversion period instrument refers to xix, xxinstrument xviii Nominal Delta Total (A+B+C) Number of voting rights Percentage of voting rights 9,646,302 10.1% 9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi Woodford Investment Management LLP as Investment Manager Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will ceaseto hold: 12. Date on which proxy holder will cease to holdvoting rights: 13. Additional information: 14. Contact name: Jon Webb 15. Contact telephone number: 01865 809023