Director/PDMR Shareholding

e-Therapeutics plc ("e-Therapeutics" or the "Company")

Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons

The Company was informed on 1 March 2011 that Steve Self, an Executive Director, purchased 16,547 ordinary shares on 23 February 2011 at 36.25p per share and 19,866 shares on 28 February 2011 at 37.75p per share. His resultant total holding is 36,413 shares representing 0.05% of the issued share capital of the company.

2 March 2011.

For more information, please contact:

e-Therapeutics plc

Malcolm Young / John Cordiner

Tel: +44 (0) 191 233 1317

E-mail: malcolm@etherapeutics.co.uk

www.etherapeutics.co.uk

Panmure Gordon (UK) Limited

Andrew Burnett / Aubrey Powell

Tel: +44 (0) 20 7459 3600

www.panmuregordon.com