Block listing Interim Review

Name of applicant:

ASTRAZENECA PLC

Name of scheme:

ASTRAZENECA SHARE OPTION PLAN; ASTRAZENECA SAVINGS-RELATED SHARE OPTION PLAN; ASTRAZENECA ALL-EMPLOYEE SHARE PLAN; ASTRAZENECA PLC 2012 SAVINGS-RELATED SHARE OPTION SCHEME

Period of return:

From:

31 MAY 2016

To:

30 NOVEMBER 2016

Balance of unallotted securities under scheme(s) from previous return:

4,065,743

Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

0

Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

478,408

Equals: Balance under scheme(s) not yet issued/allotted at end of period:

3,587,335

Name of contact:

MARTIN BENNETT

Telephone number of contact:

07825 530066

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