26 Jun 2017 07:00
Press release June 26, 2017
Verseon Corporation
("Verseon" or the "Company")
Verseon presents preclinical data on diabetic macular edema candidates at BIO 2017
Fremont, Calif.-Verseon presented pharmacokinetic and in vivo efficacy data on its diabetic macular edema (DME) candidates at the 2017 BIO International Conference last week. The data suggest that Verseon's drug candidates reduce leakage into the retina and are suitable for topical or oral dosing.
Verseon is developing plasma kallikrein inhibitors for the treatment of DME, a major cause of vision loss in persons with diabetes mellitus. Weakened blood vessels caused by chronically high blood sugar can lead to fluid leaking into the retina, which may result in swelling, blurred vision, and eventually central vision loss associated with DME. By targeting the serine protease plasma kallikrein, a validated disease pathway, Verseon's drug candidates treat an underlying cause of DME.
At the BIO conference, Verseon presented an in vivo efficacy study with systemic dosing, which indicates that the Company's drug candidates reduce leakage into the retina and decrease mean circulation times, suggesting a slowing of the disease progression. Dr. David Kita, Vice President of R&D at Verseon, also presented pharmacokinetics for two series of drug candidates, which show good exposure in the relevant tissues of the eye when administered topically. Some of the Company's candidates also show high oral bioavailability.
A second presentation covered recent preclinical results in Verseon's anticoagulation program. The Company showed efficacy and safety data for its first development candidate for clinical trials and presented preclinical data on another promising lead candidate with a distinct chemotype.
About Verseon's diabetic macular edema program
Verseon has developed a new class of potent, selective compounds for the treatment of diabetic macular edema. The Company's plasma kallikrein inhibitors target a validated pathway addressing an underlying cause of the disease. In preclinical testing, Verseon's inhibitors show favorable biochemical properties permitting either oral or topical (eye drop) administration.
About Verseon's anticoagulation program
Verseon's potent, highly selective, oral direct thrombin inhibitors act through reversible covalent inhibition, a unique mode of action. Preclinical studies show that Verseon's inhibitors act as effective anticoagulants in multiple efficacy studies, but do not disrupt platelet function. This unique feature could explain their observed low bleeding risk. One of Verseon's lead candidates furthermore shows very low renal clearance, a highly desirable property for patients with impaired renal function.
About Verseon
Verseon Corporation (www.verseon.com, AIM: VSN) is a technology-based pharmaceutical company that employs its proprietary, computational drug discovery platform to develop novel therapeutics that are unlikely to be found using conventional methods. The Company is applying its platform to a growing drug pipeline and currently has three active drug programs in the areas of anticoagulation, diabetic macular edema, and oncology.
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Verseon Corporation | www.verseon.com |
Tina Schlafly | +1 (510) 225 9000 |
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Forward-Looking Statements
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