Sphere Medical Holding Regulatory News (SPHR)

For Immediate Release 11 December 2014

Sphere Medical Holding plc

Professor Michael Quintel joins Medical Advisory Board

~ Appointment of leading clinician from Germany ~

Cambridge, UK, 11 December 2014: Sphere Medical Holding plc (AIM: SPHR.L) ("Sphere Medical"), a leading developer of innovative monitoring and diagnostic products for the critical care setting, today announces the appointment of Professor Michael Quintel to its Medical Advisory Board.

Professor Quintel is a leading clinician within the German and European intensive care profession. He is the Director of the Department of Anaesthesiology, Emergency and Intensive Care Medicine at the University of Göttingen, Germany. Professor Quintel is also a member of the European Society of Intensive Care Medicine (ESICM) group on respiratory failure, a member of the Scientific Committee of International ECMONet, Past President of the German Interdisciplinary Society of Intensive Care Medicine (DIVI) and a past council member of the German Society of Anaesthesia and Intensive Care (DGAI). Professor Quintel is also a member of the German Sepsis Society and an Investigator in the SepNet Sepsis Clinical Trial Network in Germany and has participated in numerous sepsis and critical care trials.

Professor Quintel will work alongside Professor Jean-Louis Vincent, Professor of Intensive Care at the Université Libre de Bruxelles and the Head of the Department of Intensive Care, Erasme University Hospital (University of Brussels) and Dr Tom Clutton-Brock, Head of Anaesthesia & Intensive Care at The University of Birmingham Medical School and Associate Medical Director at the University Hospital Birmingham NHS Foundation Trust.

Commenting on this appointment, Sphere Medical's Chief Executive Officer, Wolfgang Rencken, said:"Professor Quintel's appointment to Sphere Medical's Medical Advisory Board complements our strategy of commercialising Proxima in the European market. We look forward to drawing upon Professor Quintel's extensive experience within the German intensive care profession, in particular, his work on sepsis as this is one of the market segments we are initially focussing on."

Professor Quintel added:"Proxima addresses some important issues in the management of unstable critically ill patients. I look forward to advising Sphere Medical on this exciting development in critical care."

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Notes for Editors

Sphere Medical (AIM: SPHR.L), is a medical device company developing a range of innovative monitoring and diagnostic devices designed to significantly improve patient care.

Sphere Medical's products deliver real time analysis of blood gases, electrolytes and drug levels with laboratory accuracy, at the patient's bedside. Sphere Medical's products can be used in a wide range of medical applications, enabling faster clinical decision making and improved patient outcomes, whilst reducing costs for healthcare payers.

Sphere Medical entered into a collaboration agreement with Ortho-Clinical Diagnostics, Inc. for the development of Proxima and enhancement of Sphere's operational and production capabilities in 2013.

Sphere Medical has a number of partnerships with industry leading medical device companies and has received a strategic investment from Ortho Clinical Diagnostics (now part of Carlyle Group). Other significant investors include Life Sciences Partners (LSP Life Sciences Fund).

For further information, please visit www.spheremedical.com