Sareum Regulatory News (SAR)

SAREUM HOLDINGS PLC

("Sareum" or "the Company")

CHK1 Clinical Trial Application Submissions

Sareum, the specialist cancer drug discovery and development business, is pleased to announce that, further to the Company's announcement of 15 December 2015, the Clinical Trial Applications for Phase I clinical trials of CCT245737, the CHK1 Programme clinical development candidate drug, were submitted to the UK Medicines and Healthcare products Regulatory Agency (MHRA) on 29 January 2016.

These Clinical Trial Application submissions trigger a £200,000 success milestone payment from Cancer Research Technology Ltd to Sareum.

As reported previously, two clinical trials in cancer patients are planned, one with CCT245737 as a single anti-cancer agent and one in combination with standard-of-care chemotherapy. Once approval is obtained, these trials will be funded in collaboration with co-development partner, the CRT Pioneer Fund. In accordance with the CHK1 co-investment agreement, Sareum satisfied a financial commitment of £797,500 to the funding of this development phase in December 2015.

Sareum's CEO, Dr Tim Mitchell, commented: "We are delighted to report a further significant step towards these two planned clinical trials with cancer patients and are very pleased to have earned this success milestone." 

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Notes for editors:

Sareum is a drug discovery and development company delivering targeted small molecule therapeutics, focusing on cancer and autoimmune disease, for licensing to pharmaceutical and biotechnology companies at the preclinical or early clinical trials stage.

Sareum operates an outsourced research model, working with collaborators (SRI International, the CRT Pioneer Fund and Hebei Medical University Biomedical Engineering Center) and a world-wide network of research providers. Its research pipeline includes two programmes undergoing pre-clinical IND-enabling studies.

SKIL® (Sareum Kinase Inhibitor Library) is Sareum's drug discovery technology platform that has so far produced the Company's Aurora+FLT3, Aurora+ALK, VEGFR-3, FLT3 & TYK2 kinase cancer and autoimmune disease research programmes. SKIL® can also generate drug research programmes against other kinase targets.

Sareum Holdings plc is listed on the AIM market of the London Stock Exchange, trading under the symbol SAR. For further information, please visit www.sareum.co.uk

Checkpoint Kinase 1 (CHK1) is important in controlling the way many cancer cells respond to DNA damage, which may be a consequence of the cancer itself, or intentionally caused by chemotherapy or radiotherapy. Inhibition of CHK1 affects the ability of the cell to repair this damage and can therefore potentiate the effect of certain chemotherapeutic drugs. The clinical candidate CHK1 inhibitor, known as CCT245737, could potentially treat a range of cancers including pancreatic, bowel and non-small cell lung cancer (NSCLC) in combination with DNA-damaging chemotherapy drugs and/or radiotherapy. The inhibitor could also potentially treat certain neuroblastoma, lymphoma and acute myeloid leukaemia (AML) types when dosed alone.