Sant Uk.10te% Regulatory News (SAN)

SANTANDER UK PLC€35 BILLION GLOBAL COVERED BOND PROGRAMMEPublication of Final Terms - Series 66

The following final terms (the Final Terms) are available for viewing:

Issue of Series 66 Tranche 2 £500,000,000 Floating Rate Covered Bonds due 16 November 2022 (ISIN XS1749371685), to be consolidated, become fungible and form a single Series with the existing Series 66 Tranche 1 £500,000,000 Floating Rate Covered Bonds due 16 November 2022 issued on 16 November 2017 (ISIN XS1719070390), under the €35 billion Global Covered Bond Programme of Santander UK plc (the Programme).

To view the full Final Terms document, please click on or paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/0551C_-2018-1-16.pdf

A copy of the above Final Terms has been submitted to the National Storage Mechanism and will shortly be available for inspection at www.Hemscott.com/nsm.do.

The Final Terms can also be viewed via:

http://www.santander.co.uk/uk/about-santander-uk/debt-investors/abbey-covered-bonds 

Please see Annex 1 to this notice for additional information in relation to the Series 66 Tranche 2 Covered Bonds.

For further information, please contact:

Medium Term FundingSantander UK plc2 Triton SquareRegent's PlaceLondon NW1 3AN

Tel: +44 (0) 20 7756 7100

Email: mtf@santander.co.uk

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Final Terms and the base prospectus published in respect of the Programme on 2 June 2017, as supplemented on 28 July 2017, 14 September 2017 and 26 October 2017 (the Prospectus) may be addressed to and/or targeted at persons who are residents of particular countries only (as further specified in the Prospectus) and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Final Terms and the Prospectus is not addressed. Prior to relying on the information contained in the Final Terms and the Prospectus you must ascertain from the Final Terms and the Prospectus whether or not you are part of the intended addressees of the information contained therein. Your right to access this service is conditional upon complying with the above requirement.

ANNEX 1

ADDITIONAL INFORMATION IN RELATION TO SERIES 66 TRANCHE 2 £500,000,000 FLOATING RATE COVERED BONDS DUE 16 NOVEMBER 2022

OPERATIONAL INFORMATION DOCUMENT

This Operational Information Document related to the Final Terms dated 15 January 2018 (the Final Terms) in respect of the issue of Series 66 Tranche 2 £500,000,000 Floating Rate Covered Bonds due 16 November 2022 (ISIN XS1749371685).

This Operational Information Document has not been reviewed or approved by any competent authority for the purposes of the Prospectus Directive or otherwise and does not form part of the Final Terms for the purposes of the Prospectus Directive. However, for all other purposes this Operational Information Document must be read in conjunction with the Final Terms. Words and expressions which have a defined meaning in the Final Terms or Base Prospectus dated 2 June 2017, as supplemented on 28 July 2017, 14 September 2017 and 26 October 2017 have the same meanings in this Operational Information Document.

MIFID II product governance / Professional investors and ECPs only target market Solely for the purposes of each manufacturer's product approval process, the target market assessment in respect of the Covered Bonds has led to the conclusion that: (i) the target market for the Covered Bonds is eligible counterparties and professional clients only, each as defined in Directive 2014/65/EU (as amended, MiFID II); and (ii) all channels for distribution of the Covered Bonds to eligible counterparties and professional clients are appropriate. Any person subsequently offering, selling or recommending the Covered Bonds (a "distributor") should take into consideration the manufacturers' target market assessment; however, a distributor subject to MiFID II is responsible for undertaking its own target market assessment in respect of the Covered Bonds (by either adopting or refining the manufacturers' target market assessment) and determining appropriate distribution channels.

DISTRIBUTION

(a) If syndicated, names of Lead Managers: Banco Santander, S.A.RBC Europe LimitedThe Royal Bank of Scotland plc (trading as NatWest Markets)(each a "Lead Manager" and together, the "Managers")

(b) Date of Subscription Agreement: 15 January 2018

(c) If not syndicated, name of relevant Dealer: Not applicable

(d) U.S. Selling Restrictions: Regulation S