Genedrive Regulatory News (GDR)

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Epistem Holdings plc

2. Reason for the notification  (please tick the appropriate box or boxes)

An acquisition or disposal of voting rights 

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

x

3. Full name of person(s) subject to the notification obligation:

Octopus Investments Nominees Limited

4. Full name of shareholder(s) (if different from 3.):

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

27 November 2009

6. Date on which issuer notified:

1 December 2009

7. Threshold(s) that is/are crossed or reached:

5%

8. Notified details:

n/a

A: Voting rights attached to shares

Class/type of shares 

 if possible using the ISIN CODE

Situation previous to the Triggering transaction 

Resulting situation after the triggering transaction

Number of Shares 

Number of Voting Rights 

Number of shares 

Number of voting rights 

% of voting rights

Direct

Direct

Indirect 

Direct

Indirect

GB00B1VKB244

364,300

364,300

364,300

364,300

 -

4.59%

-

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument 

Expiration date 

Exercise/ Conversion Period/ Date 

Number of voting rights that may be acquired if the instrument is exercised/ converted. 

% of voting rights

-

-

-

-

-

Total (A+B)

Number of voting rights

% of voting rights

364,300

4.59%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

n/a

Proxy Voting:

10. Name of the proxy holder:

n/a

11. Number of voting rights proxy holder will cease to hold:

n/a

12. Date on which proxy holder will cease to hold voting rights:

n/a

13. Additional information:

-

14. Contact name:

Russell Jarvis

15. Contact telephone number:

020 7710 8653

16. Contact at Epistem Holdings Plc

Matthew Walls

+44 (0) 7887 501 998