ETX.L Regulatory News (ETX)

e-Therapeutics plc("e-Therapeutics" or the "Company")

Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons

The Company was informed on 20 May 2011 that Steve Self, an Executive Director, purchased on 18 May 2011 20,189 ordinary shares at 36.9p per share. His resultant total holding is 183,279 shares representing 0.13% of the issued share capital of the company which currently stands at 137,193,547 shares all carrying voting rights.

23 May 2011.

For more information, please contact:

e-Therapeutics plc

Malcolm Young

Tel: +44 (0) 191 233 1317

E-mail: malcolm@etherapeutics.co.uk

www.etherapeutics.co.uk

Panmure Gordon (UK) Limited

Andrew Burnett / Aubrey Powell

Tel: +44 (0) 20 7459 3600

www.panmure.com