Creo Medical Regulatory News (CREO)

China Real Estate Opportunities plc

Significant shareholder notification

In accordance with Rule 17 of the AIM Rules, China Real Estate Opportunities plc ("CREO" or the "Company") announces that on 26 March 2010 it was notified by a director and a significant shareholder of the following change in one of its significant shareholders.

On 22 March 2010, Treasury Holdings transferred its interests in Daylasin Limited to Richard Barrett, a director of the Company, and John Ronan, a significant shareholder in the Company. Mr Barrett and Mr. Ronan each hold 50 per cent of the shares in Treasury Holdings and, following this transaction, Daylasin Limited respectively.

Daylasin holds 5,345,819 ordinary shares of no par value in the Company, representing 11.13 per cent of the issued share capital of the Company. The price paid by Mr. Barrett and Mr. Ronan for their interests in Daylasin Limited equates to 348p for each share in the Company held by Daylasin Limited.

Following this transaction, Richard Barrett remains interested in 8,955,518 ordinary no par value shares representing 18.64 per cent of the issued share capital of the Company, John Ronan remains interested in 11,610,008 ordinary no par value shares representing 24.17 per cent of the issued share capital of the Company, and Treasury Holdings has no further interests in the Company.

Contact:

CREO

Ray Horney, Chairman

Tel: +44 (0) 1273 775 225

Sarah Moriarty, Investor Relations

Tel: + 353 1 618 9455

Matrix Corporate Capital LLP

Paul Fincham, Rob Naylor

Tel: +44 (0) 20 3206 7000

Davy

Des Carville

Tel: +353 1 679 6363

Citigate Dewe Rogerson Limited

Tom Baldock

Tel: +44 (0) 20 7638 9571

Murray Consultants

Ed Micheau

Tel: +353 1 498 0300