Aptitude Regulatory News (APTD)

MICROGEN PLC

27 SEPTEMBER 2018

BLOCK LISTING 6-MONTHLY RETURN

Name of Applicant: MICROGEN PLC

Name of Scheme: MICROGEN PLC PERFORMANCE SHARE PLAN 2006

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006

MICROGEN PLC SAVE AS YOU EARN SCHEME 2016 & INTERNATIONAL SHARESAVE SCHEME 2016

Period of return: From: 25 MARCH 2018 To: 24 SEPTEMBER 2018

Balance under scheme from previous return:

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 37,950 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 92,177 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC SAVE AS YOU EARN SCHEME 2016 AND INTERNATIONAL SHARESAVE SCHEME 2016 - N/A

The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return:

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 1,532,500 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 0 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC SAVE AS YOU EARN SCHEME 2016 AND INTERNATIONAL SHARESAVE SCHEME 2016 - 100,000 ORDINARY SHARES OF 6 3/7P EACH

Number of securities issued/allotted under scheme during period:

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 17,243 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 16,665 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC SAVE AS YOU EARN SCHEME 2016 & INTERNATIONAL SHARESAVE SCHEME 2016 - 0 ORDINARY SHARES OF 6 3/7P EACH

Balance under scheme not yet issued/allotted at end of period:

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 1,553,207 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 75,512 ORDINARY SHARES OF 6 3/7P EACH

MICROGEN PLC SAVE AS YOU EARN SCHEME 2016 & INTERNATIONAL SHARESAVE SCHEME 2016 - 100,000 ORDINARY SARES OF 6 3/7P EACH

Number and class of securities originally listed and the date of admission:

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 127,460 ORDINARY SHARES OF 5P EACH - 7 SEPTEMBER 2009

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 142,001 ORDINARY SHARES OF 5P EACH - 7 SEPTEMBER 2009

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 650,000 ORDINARY SHARES OF 5P EACH - 24 SEPTEMBER 2010

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 350,000 ORDINARY SHARES OF 5P EACH - 24 SEPTEMBER 2010

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 237,517 ORDINARY SHARES OF 5P EACH - 10 OCTOBER 2011

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 184,674 ORDINARY SHARES OF 5P EACH - 10 OCTOBER 2011

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 397,991 ORDINARY SHARES OF 5P EACH - 18 OCTOBER 2011

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 1,000,000 ORDINARY SHARES OF 5P EACH - 18 OCTOBER 2011

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 70,917 ORDINARY SHARES OF 5P EACH - 13 OCTOBER 2014

MICROGEN PLC COMPANY SHARE OPTION PLAN 2006 - 49,384 ORDINARY SHARES OF 5P EACH - 13 OCTOBER 2014

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 1,722,500 ORDINARY SHARES OF 6 3/7P EACH - 25 NOVEMBER 2016

MICROGEN PLC PERFORMANCE SHARE PLAN 2006 - 1,532,500 ORDINARY SHARES OF 6 3/7P EACH - 7 SEPTEMBER 2018

MICROGEN PLC SAVE AS YOU EARN SCHEME 2016 & INTERNATIONAL SHARESAVE SCHEME 2016 - 100,000 ORDINARY SHARES OF 6 3/7P EACH - 7 SEPTEMBER 2018

Total number of securities in issue at the end of the period:

60,895,354 ORDINARY SHARES OF 6 3/7P EACH

Name of contact: PHILIP WOOD, COMPANY SECRETARY

Address of contact: OLD CHANGE HOUSE, 128 QUEEN VICTORIA STREET, LONDON, EC4V 4BJ

Telephone number of contact: 020 7496 8100

www.microgen.com