65WK.L Regulatory News (65WK)

NOTICE OF CANCELLATION

Santander UK plc (the "Issuer")

£20,000,000 Equity Index Linked Notes due January 2028

XS2403519783

(the "N&C Securities")

This notice relates to the abovementioned N&C Securities issued by the Issuer under the base prospectus relating to its Notes and Certificates Programme dated 4 October 2021 (the "Base Prospectus") and the final terms relating to the N&C Securities dated 8 November 2021 (the "Final Terms").

Notice is hereby given that following the end of the Offer Period (as defined in the Final Terms) relating to the N&C Securities the Issuer will cancel the N&C Securities in a principal amount of £19,017,723 with immediate effect and that consequently following such cancellation the aggregate principal amount of the N&C Securities which remains outstanding will be reduced to £982,277.

For further information, please contact:

Structured Notes Desk

Tel: +44 (0) 20 7756 7000 or structurednotesafm@santander.co.uk.

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Base Prospectus and Final Terms may be addressed to and/or targeted at persons who are residents of particular countries (specified in the Base Prospectus and/or the Final Terms) only and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Base Prospectus and/or the Final Terms is not addressed. Prior to relying on the information contained in this notice, the Base Prospectus and/or the Final Terms, you must ascertain from the Base Prospectus and/or the Final Terms whether or not you are part of the intended addressees of the information contained therein.

Your right to access this service is conditional upon complying with the above requirement.

Neither the Base Prospectus nor the Final Terms referenced herein constitutes an offer of securities for sale in the United States. The securities described herein have not been, and will not be, registered under the U.S. Securities Act of 1933, as amended (the "Securities Act"), or under any relevant securities laws of any state of the United States of America, and may not be offered or sold to U.S. persons or to persons within the United States of America, except pursuant to an exemption from the Securities Act.

END