Member Info for Wildforce

I agree scancell certainly spent all their efforts getting citrulination over the line .. but doesn’t moditopes broad coverage still cover the potential of the others despite not being prioritised !? We have been repeatedly informed that moditopes intellectual property coverage is indeed broad !

Thanks for yr observations as ever !

Take care ..

With vaccines having been ‘off the menu’ for several years, imagine if big pharma now did a U turn … and in the background for all these years scancell has been pushing on against the tide, continually ‘progressing’ it’s IP !!

Who would be really playing ‘catch up’ !?

Take care all ..

These are the PTM’s cited in scancells broad patent for moditope ..

“Anti-tumour immune responses to modified self-epitopes The present invention relates to the use of tumour-associated epitopes in medicine and in particular in the treatment of cancer. The epitopes stimulate an immune reaction against the tumour and have a modification selected from deimination of arginine to citrulline, nitration of tyrosine, oxidation of tryptophan and deamination of glutamine or asparagine. The invention also relates to nucleic acids comprising sequences that encode such epitopes for use in the treatment of cancer.”

Take care all .. the market doesn’t seem to think so but these are exciting times in the development of scientific medicine !

Crumbs.. thanks for posting that and it led me to look up if there is much else going on out there regarding targeting post translational modifications (directly or indirectly) and I came across this recently published piece.

https://www.jbc.org/article/S0021-9258(23)00214-4/fulltext

Just wondering if the authors of this are aware of scancells patents?

Always good to see third party interest / validation of the ‘promise’ of the science ?

Any thought Berm / Burble ?

Take care all !

Morning all !! cc .. thanks for sharing that. A nice read on Father’s Day ! Rats, would be strange indeed for LD to draw attention to scancell like this, and then ‘produce’ nothing?

Take care all !

Bob .. post rec , needs no more explaining !

Take care ..

Nice hurdle negotiated .. cohort 3 is checkpoint inhibitor with low dose modi 1 ..

No trial halting concerns and nice to hear first patient dosed in the high dose combo , cohort 4 !

Really looking forward to seeing more data as and when it arrives.

Well done scancell ..

Take care all!

Crumbs .. my thoughts precisely .. ‘so far so good’ ..

It’s been a period of relative quiet so .. update this week perhaps??

Take care all ..

Hi cleaner ! .. it certainly is ! Thanks for sharing!

Take care ..

.. there is nothing to argue about ‘in’ the article ! I certainly feel more comfortable using the patients name now anyway .. she can’t be as upset about her case being ‘public’ as I thought ?

Good for her I say ..

Take care all ..

Morning all .. such an uplifting article .. When you consider the feelings this positive result (so far) has had, not just on the individual, but on their wider family and friends, it puts a smile on your face.

Seeing pictures of the real people involved also has an impact ..

Nothing negative here ..

Let’s hope other sufferers can benefit in the future too.

Take care all ..

That’s great news cleaner ! such a relief for you!

Take care ..

Hi Cleaner ! Had a busy few days down in sunny Devon over the bank holiday weekend .. sending you my best wishes !

Looking forward to updates from scancell … whenever they arrive! Hopefully not too long til an update on modi1 ..

Take care !

Embargo not ended yet?

Take care ..

Berm ! Thanks for sharing that .. it’s one heck of a document .. the short conclusion at the end is pretty much all we need to know I guess lol !

Take care ..

Morning all .. this is just for information and it’s probably been posted before. New information tightly controlled?

https://www.aacr.org/about-the-aacr/newsroom/annual-meeting/embargo-policy/

I guess we should have an RNS of some sort next week ?

Take care all ..

Morning Ray , yes it’s immunobody’s Scib1 that RG said was great at ‘mopping up’ micro metastasis.. Moditopes early promise seems to be the larger the tumour, the better it is ? (In mice anyway) ..

With all the ‘correct’ understanding that LD has demonstrated to date, I would think scancells understanding of their antibody portfolio would be no different. ! Here’s to more ‘deals’ lol ..

Take care all and only my thoughts as ever ..

Scancells relationship with Genmab worth a recap ..
RG’s interview from minute 11.14 ish ..

https://m.youtube.com/watch?v=oGBn9pStUYs

Take care all ..

While it’s quiet, I was just looking up any recent articles to which LD has contributed. I came across this. Whilst it’s quite in depth and not many will follow it all , it’s just a great demonstration of the knowledge you invest in when you buy a scancell share.

It’s worth a scan..

https://academic.oup.com/discovimmunology/article/2/1/kyac011/6874811

Take care all ..

Morning Dalester, I believe the list of names are just who contributed to the research or put their name to it.. usually, it’s the underlined name that will be in attendance I think?

Take care ..