RE: Pay attention to the facts1 Jul 2020 11:30
As certain new posters, such as JJMills, try to plant doubt, it is worth remembering the facts.
Regarding US manufacture, pay specific attention to Fact 1 below, then ask yourself why JJMills may be questioning the reality.
separate/independent sources advising;
Fact 1:
The Affimer reagents have worked well in lateral flow test strips and Cytiva are VERY encouraged by the initial data.
Source: Klaus Hochleitner, Global Lead, Technology Product Specialist at Cytiva
Fact 2:
Adeptrix are excited to apply Avacta's Affimer reagents to monitor COVID-19 infection because they are very well suited for large-scale manufacturing and have stable lot-to-lot performance due to it being a recombinant technology. The BAMS assay for the spike protein serves as a useful diagnostic tool because this particular viral protein is displayed on the surface of the virus particle and directly involved in engaging host cells (via ACE2 receptor) during infection. For this reason, the same BAMS assay for the spike protein can also be used for drug development efforts to screen compounds that block interaction with host cells through the ACE2 receptor to prevent virus infection.
Source: Dr. Jeffrey C. Silva, Director of Product Development, Adeptrix Corporation
Fact 3:
The infectivity assays that Glasgow University have carried out with the Affimer reagents have gone very well and they show that there are a number of them that are potent inhibitors of a SARS-COV-2 model virus entry into human cells.
Given the excellent performance of these novel reagents in the assays, and the other benefits of Affimer reagents, there should be considerable interest from potential partners in developing them as a therapy for COVID-19
Source: Professor David Bhella, Professor of Structural Virology (Centre for Virus Research) at the University of Glasgow
Fact 4:
Following the optimisation of the lateral flow test by Cytiva the design will then be transferred to manufacturing partners in the UK that are currently being put in place by Avacta. The Company is working with these manufacturers to compress the normal manufacturing, clinical validation and regulatory timelines in order to bring a product to market as quickly as possible.
Source: Sir Al, CEO
It is all there in black and white, simple to understand.
Ignore the noise, focus on the facts.