RE: PXS and other Co's !7 Jan 2022 18:54
gixer
First time I have seen FF referred to as a pharmaceutical preparation
https://www.mdpi.com/1422-0067/23/2/605/pdf
Received: 11 November 2021
Accepted: 3 January 2022
Published: 6 January 2022
Impacts of Commonly Used Edible Plants on the Modulation of
Platelet Function
Dina A. I. Albadawi 1
, Divyashree Ravishankar 1
, Thomas M. Vallance 1
, Ketan Patel 2
, Helen M. I. Osborn 1,*
and Sakthivel Vaiyapuri 1,*
1 School of Pharmacy, University of Reading, Reading RG6 6UB, UK;
d.a.i.albadawi@pgr.reading.ac.uk (D.A.I.A.); divyasri.april86@gmail.com (D.R.); tmv31@cam.ac.uk (T.M.V.)
2 School of Biological Sciences, University of Reading, Reading RG6 6UB, UK; ketan.patel@reading.ac.uk
* Correspondence: h.m.i.osborn@reading.ac.uk (H.M.I.O.); s.vaiyapuri@reading.ac.uk (S.V.)
Furthermore, Zhang et al. [112] examined the antiplatelet effects of a pharmaceutical
preparation of S. lycopersicum, Fruitflow® powder in rat isolated platelets [113]. Fruitflow®
is a pharmaceutical preparation of an aqueous extract of S. lycopersicum fruits. It is available
in a syrup and powder form and it mainly consists of active ingredients, adenosine, chlorogenic
acid, rutin and lycopene all of which are reported to have antiplatelet effects [108]. At
concentrations of 4 and 6 g/L Fruitflow® inhibited by around 55% and 74%, respectively
in 2.5 M ADP-induced platelets. However, in collagen stimulated platelets, aggregation
was reduced by 40% and 71%, respectively. Additionally, the binding of fibrinogen to
integrin IIb 3 was significantly inhibited by 32% at 6 g/L of Fruitflow® in 10 M ADP
activated isolated platelets. Moreover, the antiplatelet effects of Fruitflow® were tested
in 2.5 M ADP-induced isolated platelets after 4 weeks of oral administration of 25, 75
and 150 mg/kg doses of Fruitflow®. The 150 mg/kg dose markedly inhibited platelet
aggregation to 24% [114]
WS
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