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Tim's all pixx and wind.
Quite right, where is the rich news vein we were promised. All the previous apologies for poor management seem to mean nothing. Mr McCarthy start to deliver, please.
From an informed source:- Looks like the prior dose ranging was either off base, (too low); and / or their clinical readout assays were ineffective. If the dose was too low, then they will have to re-run the trial, using a bridge, which may be acceptable based on prior safety data. Or maybe their dose was sufficient and the assay selected to measure the endpoints was inconsistent to the extent it could not measure efficacy, i.e they did not validate it sufficiently. Frequently the clinical assays are not seen as being as important as the drug product itself, when in actual fact they are. All of these options are why the FDA advice is so significant and detailed.
Either way, they are going to have to invest more into the development. The fact Lupuzor has fast track status has no bearing on MOA, as this is based on medical need --- need to be cautious of that fact. The Drug Master File and Investigator Brochure is also likely to be required to be amended pending material differences from the repeated clinical work.
Mini nuclear are being produced by Rolls Royce so the expertise is there, what is needed from Harbours shareholders point of view is a vision for the future of the business not just more of the same.
It's worse than that. When Sizewell B was started the GEGB had plans to move sequentially on to Hinkley and then four more nuclear sites, each time expecting to benefit from the building experience. Environmental protestors and the length of the public enquiry system eventually persuaded the then Conservative government to stop the programme. So the environmentalist and a weak shortsighted government have shot themselves in the foot and caused us the current problem .
Worse still we now have the French State building our nuclear infrastructure and we have no GEGB which was a really efficient infrastructure manager and I say this as a contractor to them.
Harbour should demonstrate a long term strategy for renewables which should, in my view,include Hydrogen and mini nuclear for this they need strategic partners.
Get debt free, but plan a way forward in reneweables. My thoughs are a Hydrogen plant, initially powered by our oil/gas but a JV with Rolls Royce to have a mini nuclear station to take over with the surplus going to the grid. Needs good partners but NOT the money lenders, maybe government.
I think this will show a forward thinking business and the share price should react.
When have you known Tim not be positive? It's results that count, I'm disappointed the PK trials have not yet started where is the dynamism we were promised?
This is not the first time we have had the enthusiastic Tim, I take it with the proverbial pinch of salt!
We are where we are, let's hope that at least the communications improve which might give substance to Tim's optimism.
I am with First Direct and have the same problem. I asked the basic question "have you or any HSBC companies purchased PMO during the non availability on line" I got an equivocal reply so tried again but still evasion, so it is now with the Ombudsman to see if they can get a straight answer. I suspect they may be filling shorts.
I reported the same problem with First Direct a week ago and have registered a complaint. Apparently I'll receive a reply by the 27th Nov!!!! Stinks.
And I can't trade as First Direct say they can't close out trades!
I just bought 6800 @ 29.1 I think this is a steal, fill your boots!!
Pharma Giles is the man. Any opinion good fellow?
And a barrel in hand is worth two in the sand!