Today's RNS reality23 May 2024 14:54
usual adult dose for soft tissue sarcoma
note: several dosage regimens exist for this drug. the information presented here is manufacturer recommended dosing. some cancers are more responsive to this drug than others. always consult institutional protocol.as a single agent: 60 to 75 mg/m2 iv over 3 to 10 minutes every 21 days
the 21 days are there to allow recovery from a massive list of horrendous side effects, amongst which it's killing healthy heart tissue.
today's rns confirms that the first cohort which received 160 mg/m2 of ava6k over a two week period (i think that's higher than a standard dose of dox, bv wil confirm) have seen no adverse safety issues.
that in itself is remarkable, yes it's only 3 patients but if they had had straight dox then in my experience they would be in a terrible state.
the final cohort in the 3 week study was 3.5 times a standard dose. again amazing, with very limited side effects.
but of course today's message gets lost again in amongst the ******.