Member Info for Tillywhiz

Popped up on Ortex - last night plenty of publicity is good ( I appreciate it’s similar info but to a new investor audience )

Hemogenyx Pharmaceuticals PLC Announces FDA Consents to Phase I Trials of HEMO-CAR-T

Stock House

10th Feb 18:36

FDA Consents to Phase I Trials of HEMO-CAR-T LONDON, UK/ ACCESSWIRE/ February 9, 2024/ Hemogenyx Pharmaceuticals plc is pleased to announce that it has been informed by the U.S.

Federal Food and Drug Administration ("FDA") that it has lifted the clinical hold on the Investigational New Drug (IND) application for HEMO-CAR-T for the treatment of acute myeloid leukemia ("AML"). The FDA confirmed that the Company had addressed all issues identified in its prior clinical hold letter satisfactorily and consents to the Company proceeding with its Phase I clinical study of HEMO-CAR-T.

Dr Vladislav Sandler, CEO & Co-Founder of Hemogenyx Pharmaceuticals, commented: "We are extremely pleased with the FDA's decision to lift the clinical hold. We now look forward to accelerating clinical development of HEMO-CAR-T and to offering patients a potentially life-saving treatment. The removal of the clinical hold was made possible by the hard work and dedication of the entire Hemogenyx Pharmaceuticals team and its Board of Directors and advisors."

About AML and CAR-T Therapy

AML, the most common type of acute leukemia in adults, has poor survival rates (a five-year survival rate of less than 30% in adults) and is currently treated using chemotherapy, rather than the potentially more benign and effective form of therapy being developed by Hemogenyx Pharmaceuticals. The successful development of a new therapy for AML would have a major impact on treatment and survival rates for the disease.

CAR-T therapy is a treatment in which a patient's own T-cells, a type of immune cell, are modified to recognize and kill the patient's cancer cells. The procedure involves: isolating T-cells from the patient; modifying the isolated T-cells in a laboratory using a CAR gene construct (which allows the cells to recognize the patient's cancer); amplifying (growing to large numbers) the newly modified cells; and re-introducing the cells back into the patient.

Fetch the CAR T Clinical Grog

Morning All

Great upward trend over last 4 months since Prevail got involved & since then now clinical on CAR T - the seas in front certainly look blue

As per recent trading update I posted from Ortex Friday

1 week increase 18%

2 week increase 40%

Hemo - has increased 90% compared to its biotech peers in last month

RSI at 75 shows strength

Volume 129 million 15 times above 3 month average

Stock price 90% up on year

& 3 month price graph since Prevail got involved showing strong uptrend & reflected in above figures & after Fridays Shenanigans with 129 million traded & quality RNS I would expect the north trajectory to continue over coming weeks .

Multi pronged science gaining traction for sure-

CAR T - unfolded & into clinical

CBR - cooking

CDX -cooking

All making superb progress & Prevail underpinning with pharmas deals / partnerships likely in the pipeline & soon .imo

Fetch the weekend Throat massager

Morning all invested

What a volatile week , however did bag a superb RNS all though not yet perhaps recognised by the markets .As Pawking has noted 130 million traded yesterday with every toxic trader & CFD fiddler on LSE turning up to milk the RNS udders ,

likely in both directions flipping the trades hence the toxicity on here most of the session .

Anyhow ,the RNS will sink in & no doubt another RNS with a forward clinical plan via Prevail in the pipeline .

Ortex update on trading -

Hemogenyx Pharmaceuticals (HEMO) has recently displayed remarkable volatility compared to its biotech peers,

surging 86.47% more in the last month.

Trading activity soared, with the last day's trading volume hitting 129,888,900 shares, dwarfing the three-month average by over fifteen-fold.

The company has also captured significant attention in the news and on social media in the past day.

Over the past week, HEMO has achieved an 8.36% price increase,

its Year-To-Date price change standing at 71.96%, accompanied by a notably high Relative Strength Index (RSI) of 73.75.

The Stock will re rate as more news lands & been a great start to 2024 for all invested

CAR T - Boiling

CDX & CBR - cooking

Fetch the Weekend Full English with all the trimmings including Black pudding mmmm…..

Gheko

Sorry for loss

A genuine heart felt post

unfortunately this hideous disease effects so many of us & our families & hopefully Hemo can bring a cure into the world saving many lives & parting the dark clouds of pain & suffering .

Evening All -

Generally on these boards & as noticed today

Unfortunately when a quality stock begins to bare fruit , you get the poisonous toads turning up with keyboard in one hand & small pecker in the other , green with envy & reeking of agenda

Greed brings the worst out in toxic human behaviour & plenty of examples on these chat forums for sure as seen today .

I am a dad & grandad & live on a boat , hence the nautical banter - some just don’t get it , it’s harmless humour while we all try to make a few bucks in these unforgiving markets .

Anyhow

Only the beginning for CAR T & Hemo investors - underpinned by Prevail

& in the background CBR & CD X still cooking

Fetch the finest weekend Grog

Another kipper landed

Date Time Trade Prc Volume Buy/Sell Bid Ask Value

09-Feb-24 15:16:46 3.9851 1,000,000 Unknown* 3.81 4.10 39.85k O

A few delayed kippers slapping on deck

Date Time Trade Prc Volume Buy/Sell Bid Ask Value

09-Feb-24 16:15:31 4.011 400,000 Unknown* 3.81 4.10 16.04k O

09-Feb-24 09:31:04 4.81 1,000,000 Unknown* 3.81 4.10 48.10k O

09-Feb-24 09:27:00 5.14 967,788 Unknown* 3.81 4.10 49.74k O

09-Feb-24 08:31:43 4.5034 1,000,000 Unknown* 3.81 4.10 45.03k O

Price 4.10

Vol 126 million

Vwap 4.75

Auto vol 14 million

What a crazy days trading , investors got the clinical confirmation RNS &

Prevail underpinning

However finished flat after initial spike - Today’s crazy trading perhaps priced in RNS or just the way the market shenanigans unfold .

Next week , let’s see what occurs I’m off to get grogged up .

Hemo are Clinical on CAR T with Prevail underpinning period .

With CDX & CBR in the mix

Traders will do there thing as will MMs

Let’s see where the sp finishes today & over next week with Pharmas sniffing around with there cheque books

Fetch the CAR T throat massager I think a few need it

Guinness & all

Absolutely, thousands of delayed stock printed from earlier slapping on deck ,

Perhaps balancing trades after bonkers start this morn .

To note -

Vwap rising

Spread tightening

Let’s see what next hour brings & mms have there Friday fun

CAR T nailed for clinical

The Gutts & all

Would never divulge exactly on here with some of the bottom feeders lurking , however in Yorkshire dude - cruiser

All the best to you .

Grab a glass of clinical Grog

100 million volume reached

Vwap - 4.85

Auto vol 13 million

+41 + 11%

Expecting some large delayed kippers pm

Let’s see how the pm & weeks ahead pan out

100% + in last few weeks .

More importantly than the above - long term CAR T clinical nailed with Prevail underpinning

Friday clinical Grog for all invested

These bozo traders turn up late to the party & have to pay a premium in Hemo , Eua , etc & want to blame anyone but themselves for there poor choices

The info I post is from sources noted , try doing your own research & take responsibility for your own investment decisions ,

Pathetic human specimens for sure .

They spring up like Toxic blow up dolls in the back of Del boys van

Strange how all these toxic clowns turn up after Hemos RNS has landed , yet never been involved with the stock for months

Like I noted Greed & envy brings out worst traits in human behaviour ,

Generally on these boards ..

Unfortunately when a quality stock begins to bag , you get the poisonous toads turning up with keyboard in one hand & small pecker in the other , green with envy & reeking of agenda

Greed brings the worst out in human behaviour & plenty on these chat forums for sure ,

I am a dad m grandad & live on a boat , hence the nautical banter - some just don’t get it , it’s harmless humour while we all try to make a few quid .

Only the beginning for CAR T & Hemo investors

With CBR & CD X still cooking

Fetch the finest Grog

Starbright & all

In Hemo since 2016 - low average

In Eua since 2018 - low average

You don’t get the humour that’s your problem pal

Hemo are doing well for investors , you sound like a green eyed plonker .

Popped up on Ortex - words out on Hemo

Hemogenyx Pharmaceuticals PLC - London-based biopharmaceutical company focused on treatments for deadly blood diseases

- US Food & Drug Administration has lifted clinical hold on company's investigational new drug application for Hemo-Car-T to treat acute myeloid leukemia.

FDA placed therapy on clinical hold in July due to a splicing deficiency during manufacture of the lentivirus used to produce Car-T cells.

Hemogenyx in August produced a "detailed plan, supported by laboratory tests" to address FDA's concerns, which was accepted the following month.

Company says on Friday that the FDA has confirmed that all issues identified in its clinical hold letter have been satisfactorily addressed. FDA therefore consents to Hemogenyx proceeding with its phase 1 clinical study of Hemo-Car-T.

Chief Executive Officer Vladislav Sandler comments: "We are extremely pleased with the FDA's decision to lift the clinical hold. We now look forward to accelerating clinical development of Hemo-Car-T and to offering patients a potentially life-saving treatment."

Current stock price: 4.6 pence, up 16% on Friday morning

12-month change: 100% +

The word will be getting out there on Hemo science & subsequent stock re rate

Fetch the Grog

Prevail - obviously liked what they saw on the Hemo CAR T menu hence tossing dosh in at a premium

Now we are clinical & the pharma deals / investments begin

Fetch the CAR T throat massager

A couple of nice delayed kippers slapped on deck

Auto volume 11.5 million - currently

Date Time Trade Prc Volume Buy/Sell Bid Ask Value

09-Feb-24 09:28:34 4.82 700,000 Unknown* 4.31 4.50 33.74k O

09-Feb-24 09:28:01 4.875 588,973 Unknown* 4.31 4.50 28.71k O

Current stock 4.50 +16%

Huge volume pushing 90 million

Vwap 4.91 - barely shifted in last hour

Would expect a pm push & some huge delayed kipper trades later on

Great RNS & just the beginning on CAR T clinical with Prevail stood behind underpinning any deals .

Fetch the CAR T Grog