RE: What happened to COPD9 Mar 2022 08:40
If that is true about the COPD trial ,then surely that trial info must be contaminated with SOC data same as Sprinter.
Most ( if not all) COPD patients take regular corticosteroid therapy to relieve / prevent severe attack.. I can't for one second ,imagine that a sufferer will down tool his / her inhalers /tablets to participate in a trial that may or may not prevent them being hospitalised with severe breathing difficulties or even kill them ,depending on whether they get placebo or drug ..
Both SNG and corticosteroids work very well ..A very small amount of people become so poorly ( marsdens favourite word,) that they can no longer react to steroid therapy .Thats where SNG comes in to play and it works very well .,No debate !
.Its determining who,out of the millions of sufferers ,may or may not advance to severe illness where SNG is the savior .If the drug is already approved then thats not an issue ,
But to trial patients to get to approval is nigh on impossible unless IMHO , you trial the drug in a specific area where there is no corticosteroid SOC accessible because of cost implications . Brazil or India exclusively would have done . Not now though .
If a new cancer drug comes along which is slightly more potent than the existing cancer drug ,how can you trial this if everybody is on one of the drugs .Some people on the new drug may die because mixing the 2 drugs together caused interaction dilution to the more powerful drug ,disguising its true potency
When safety protocol is assured then surely Invitro results should take presidency over matters . Invitro testing of both SNG along with COPD and Covid SOC should and probably does reveal dilution of potency in SNG .Doesn't mean SNG doesn't work but should've meant that the trials were aborted until a rational solution could be reached . SNG001 would have without doubt saved hundreds of thousands of lives if approved .Its just impossible to prove without a large scale cohort to examine ..
Very few medical trials involve the risk of death as a possible outcome unless there is no alternative.
If someone developed an antidote to Novochok,how do you trial it .50% on antidote 50% on placebo ? You know 50% at least are going to die but all 100% are well aware its an all or nothing scenareo from the off but thats probably too simplistic as most probably the 100% would get antidote under EUA ,,,? That data would be corrupt though under current medical protocol but you discover ," Hey ,we know it works"
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