AZ phase 3 trial failure14 Nov 2023 09:34
(Sharecast News) - AstraZeneca announced on Tuesday that its 'PACIFIC-2' phase three trial for Imfinzi, or durvalumab, concurrently administered with chemoradiotherapy (CRT), did not achieve its primary endpoint of progression-free survival compared to CRT alone.
The FTSE 100 pharmaceuticals giant said the trial aimed to address the treatment of patients with unresectable stage three non-small cell lung cancer (NSCLC) who either progressed or discontinued treatment during CRT, rendering them ineligible for the established 'PACIFIC' regimen, where Imfinzi is sequentially administered after platinum-based CRT.
Initial analysis of safety and tolerability for the concurrent administration of Imfinzi and CRT in the patient population revealed profiles broadly consistent with each treatment's known profiles.