Member Info for stephen11

Surely the buys wills start winning soon................

To BUYS................

30-Mar-23 08:28:44 34.00 58,802 Buy* 33.50 34.00 19.99k O
30-Mar-23 08:28:27 34.00 5 Buy* 33.50 34.00 1.70 O
30-Mar-23 08:28:17 34.00 50,000 Buy* 33.50 34.00 17.00k O
30-Mar-23 08:28:10 34.00 3,175 Buy* 33.50 34.00 1,080 O
30-Mar-23 08:27:57 33.95 4,655 Buy* 33.50 34.00 1,580 O
30-Mar-23 08:27:41 33.90 4,000 Buy* 33.50 34.00 1,356 O
30-Mar-23 08:27:36 33.90 6,872 Buy* 33.50 34.00 2,330 O
30-Mar-23 08:27:27 33.95 851 Buy* 33.50 34.00 288.91 O
30-Mar-23 08:27:21 33.90 2,026 Buy* 33.50 34.00 686.81 O
30-Mar-23 08:27:21 33.80 10,000 Buy* 33.50 34.00 3,380 O
30-Mar-23 08:27:17 33.50 10,000 Sell* 33.50 34.00 3,350 O
30-Mar-23 08:27:17 33.80 36,194 Buy* 33.50 34.00 12.23k O
30-Mar-23 08:27:13 33.50 250 Sell* 33.50 34.00 83.75 O
30-Mar-23 08:27:05 33.75 50,000 Buy* 33.00 34.00 16.88k O
30-Mar-23 08:26:53 33.825 2,051 Buy* 33.00 34.00 693.75 O
30-Mar-23 08:26:42 33.85 3,000 Buy* 33.00 34.00 1,016 O
30-Mar-23 08:26:38 33.85 901 Buy* 33.00 34.00 304.99 O
30-Mar-23 08:26:27 33.50 50,000 Buy* 33.00 33.50 16.75k O
30-Mar-23 08:26:25 33.50 15,000 Buy* 33.00 33.50 5,025 O
30-Mar-23 08:26:18 33.50 9,520 Buy* 33.00 33.50 3,189 O
30-Mar-23 08:26:16 33.50 2,985 Buy* 33.00 33.50 999.98 O
30-Mar-23 08:26:15 33.50 17,149 Buy* 33.00 33.50 5,745 O

Genedrive said the UK National Institute for Health & Care Excellence has ratified and finalised its recommendation that the antibiotic hearing loss test, the MT-RNR1 ID kit, can be used in the UK's NHS. This follows a public consultation process last month, after NICE's preliminary recommendation. The test is used to screen infants for a genetic variant which causes lifelong hearing loss if those who carry it are dosed with certain antibiotics.

Highlights below:

https://www.nice.org.uk/guidance/hte6/chapter/1-Recommendations

- Clinical: Evidence suggests that the Genedrive MT-RNR1 ID Kit quickly and accurately identifies babies with the MT-RNR1 m.1555A>G variant, who may be at risk of hearing loss if given aminoglycoside antibiotics. This will allow equally effective alternative antibiotics to be used instead.

- Unmet need: There is currently no test available in the NHS that gives results quickly enough to inform decisions on acute antibiotic prescribing.

- Resources: The long-term savings to the NHS associated with hearing loss and fitting cochlear implants could be substantial.

- Equality: The prevalence of the genetic variant differs between ethnic backgrounds. There are also other variants associated with a risk of hearing loss. Data should be generated in centres with babies from different ethnicities to promote equality. The test should also be implemented in a wide range of geographical regions to include patients from various socioeconomic groups to ensure equal access.

LOVE THE LAST SENTENCE - should also be implemented in a wide range of geographical regions to include patients from various socioeconomic groups to ensure equal access.

Enough said.

Well said Brighty and Ldakmail - i concur

Some on here just go around with a glass half empty!

They are the sort that do the lottery ever week and worry about not winning. If they did win they would then worry about having too much money.

Very true ref: cigarette packets Bighammer - here's to a good day ahead!

I've read a few NICE reports - they put caveats in them all - nothing to worry about and all standard practice!

Have you ever read the warnings on a box of paracetamol - if you worried to much you wouldn't take them!

Highlights below:

https://www.nice.org.uk/guidance/hte6/chapter/1-Recommendations

- Clinical: Evidence suggests that the Genedrive MT-RNR1 ID Kit quickly and accurately identifies babies with the MT-RNR1 m.1555A>G variant, who may be at risk of hearing loss if given aminoglycoside antibiotics. This will allow equally effective alternative antibiotics to be used instead.

- Unmet need: There is currently no test available in the NHS that gives results quickly enough to inform decisions on acute antibiotic prescribing.

- Resources: The long-term savings to the NHS associated with hearing loss and fitting cochlear implants could be substantial.

- Equality: The prevalence of the genetic variant differs between ethnic backgrounds. There are also other variants associated with a risk of hearing loss. Data should be generated in centres with babies from different ethnicities to promote equality. The test should also be implemented in a wide range of geographical regions to include patients from various socioeconomic groups to ensure equal access.

LOVE THE LAST SENTENCE - should also be implemented in a wide range of geographical regions to include patients from various socioeconomic groups to ensure equal access.

Enough said.

It’s landed - that’s what we need.

A big positive for GDR!

Get the popcorn ready for 8am - this could get very interesting!

demolition123 - to part answer your question!

These are the most up to date figures i can find:

General UK premature birth statistics:

- Around 8% of births in the UK are preterm. That is around 60,000 babies each year.
- I don't know how many of these would need the test so i'll run some projections (additionally each machine costs £5000)
- 30,000 tests x £80 = 2.4 million annual revenue
- 20,000 tests x £80 = 1.6 million annual revenue
- 10,000 tests x £80 = £800,000 annual revenue

- WORLDWIDE - 15 million babies born preterm each year
- 1% of this global market equates to 150,000 babies (this is a very conservative estimate)
- 150,000 tests x £80 = £12 million (not including the cost of purchasing or renting the testing machine)

Food for thought!

Good man BigAl - I'll second that!

And lets see what the day will bring!

Fingers and toes crossed for a good NICE RNS with no extra surprises.

GLA

Stephen11.

Ps......i hope the rocket is on standby mode BigAl and it gets used...lol!

I'm the same onlyprofit - I've managed to average up (stupid in hindsight) and then average down over the last 3 years and have a large holding. Never sold a penny, but i'm getting a little frustrated at how long my money has been tied up.

See the long-term potential here, but just want a bit of a top slice to invest in some other share interests. I then want to let the rest of my holdings to go on a free run.

Normally when news is nailed on with a share (with a specific arrival date) you get day-traders and speculators taking a position the day before? I don't do this myself, but each to there own!

I can't understand why this isn't happening?

This is all very peculiar!

I sincerely hope not John - that would be a very low blow to long term holders indeed!

I'm hoping some success with grant funding and lower R+D spend will increase the cash runway until some natural sales revenue arrives from multiple NHS Trusts, Europe, and the World!

Come on GDR!

Any of you guys been in other medical or pharmaceutical stocks that have received NICE accreditation?....just to gauge how the SP might react?

I appreciate it's very difficult to generalise.

Anyone got that L2 trading - just wondering about the final SP - hope we have broken even?

And, here's to a better day tomorrow!

Stephen11.

What a very pleasant surprise to end up +4.4% and 40p on the button!

Hopefully we can carry this momentum into tomorrow morning.

Enjoy your extra hour of sunlight this evening,

Stephen11.

Feel #typo