Interleukin-1 and the NLRP3 inflammasome in COVID-198 Oct 2022 15:50
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00481-9/fulltext?rss=yes
In this review, we summarize current evidence supporting the involvement of the NLRP3 inflammasome and IL-1ß in the pathogenesis of COVID-19. We also discuss the therapeutic relevance of targeting IL-1ß to improve COVID-19-related outcomes.
To date, a number of experimental NLRP3 inflammasome inhibitors are currently available (MCC950, BAY 11–7082, INF4E, 16,673-34-0, OLT1177 [dapansutrile], CY-09, tranilast).
Currently available data from early phase clinical trials with specific NLRP3 inflammasome inhibitors in the cardiovascular field have shown promising results awaiting validation.