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For what i might add, i for one cannot see what they have done to deserve this. This really is marking your own homework and giving yourself 100%.

I will ask a question for the AGM regarding this but i can guarantee that as usual it will be ignored.

Totally immoral in my view

Can’t believe that we still know nothing about what happened with the failed tox study

Communication could be around what avenues they and the cro are looking at, how they are doing it and when a result is expected

As it is we have paid for the last one

We will now have to pay for the next one and both us and the market are no further forward with confidence or options to progress

Shocking behaviour

What are they all doing everyday I would still like to know

I would love to attend the meeting and hold them to account but it annoys me that I will have to pay a stupidly priced railfare to enjoy that privilege

I have asked questions at the last 2ams and at the last meeting on line recently and they never answer

So it may be the only way

It does feel that this format allows them to get away with a lot at these meetings

Complete order of business and then gone in under an hour last time

We will see

Surely the bod have an inkling of what the problem was with the toxicology trial and who was to blame and yet we have no communication to the market and us as shareholders

We are supposed to just keep quiet and hope that the new trial starts soon and is on track to get the best possible outcome

After all the promises I am staggered that nothing has changed with regards to comms

What happened to IR specialists helping with this

Also what is happening with Tim, what exactly is his part time role now and what is the succession plan

I would welcome thoughts on this as everyone else seems to be happy withe current state of affairs?

It is almost 10 years since sierra acquired this and then GSK could effectively run with it for free when they acquired the company, but chose not to and they gave it back - why?, i would be extremely surprised if any company sees that this has any value now so late in its life cycle, if anyone was going to make a move i think they would have done it by now.

I love Dr parkers terminology when he says the he is optimistic in identifying a path going forwards, very much political speak in my opinion, i hope he proves me wrong though......................

Totally agree Benhowell, a total lack of communication again and even worse for any outcomes, agree about 2025, has been very unproductive apart from salaries.

Lets hope my gut is wrong......................

I realise that these are difficult times for the company but i am disappointed in the tone of the meeting, very dour and no real positivity. Tim said very little, what does he do these days, john sounded very nervous and almost negative, the pauses in some of his answers were tangible. Reading out all of the old slides i found a bit condescending if i am honest.

It looks like another full year of more trial work etc before we get anywhere near any commercialisation from what i can tell.

Good news we have not failed totally as yet in terms of 1801, but not sure the current methodology and team are going to deliver the results we need based on that showing.

GLA, here for the long term i guess

Well said Blockbuster 1, i couldn't agree more

Roadmap, milestones, deliverables, end goals is the sort of language i think us and the market need to hear right now.

Well over a week since the rns and no further communication from the BOD, as per usual.

It staggers me the way they run the business and allow the share price to collapse to these levels. If it was their fault own up to it and lets see some sort of action plan, if it was the CRO then the same thing, what is the plan to deal with it. I bet they get to the 23rd and say they cant update us as it is sensitive information (sound of can on concrete in the background)

But to leave the market hanging and drifting i find strange, doesn't affect their salaries still though..................

I have been here for almost 20 years now and in all that time the board do still not deliver clear communication, to either us, or the marketplace and hence their customers. Personally i think the board need to resolve this issue quickly and confidently. We seem to be drifting from disaster to disaster recently, consolidation (didn't really work), RF disaster (could have got funding earlier and from elsewhere), MHRA (not sure what went on there), waiting forever for tox results and now this revelation.

This may not be there fault but they are not clear as to what is. If we as investors are frustrated and nervous you can bet customers are as well. As i have said we are starting to look like amateurs. we need to focus on finishing what we started and do it well. Putting out the AI interview only days before this gives a very bad optic.

I will stay for the moment but like many i think we need strong and confident answers swiftly, not just the usual radio silence

I thought all the big sells yesterday were suspicious, also why they looked nervous in the interview, i say again why the hell did they get massive pay rises a few years back, nothing has been achieved and probably never will now

sorry for all the long term holders

Re BenHowell - what a great post about the road map for progress and where we are. For me that is the crux of the problem, i have no idea where we are on that journey as the communication is still diabolical and it has never been made clear what the path should look like and where we are against milestones, i am sure this is deliberate so they can't be held to account.

I hope the BOD do see this board and take in the level of confusion they are creating, this must also be how the market and potential buyers view the company i would guess, we are starting to look very amateurish in my book. I can see us being a TO but at a fraction of where we should be as a result of this.

i hope to be proved wrong when they do actually create some value to shareholders and not just themselves, i will gladly say i am wrong as and when they do. I was staggered buy how much the remuneration has been when someone posted that earlier this week over a period of time, and where the share price has gone over that same period. It is not right in my opinion that they awarded themselves big increases a while back when results suggest in terms of performance it was not deserved.

I am not going anywhere as i am way underwater and it doesn't make sense to leave the ship now before anyone says you can always sell up and go elsewhere

GLA all and looking forward to being proved wrong in the very near future.

Hi Falkirkfreamer, i couldn't agree more, having reviewed the interview again i am starting to believe you are right on the button, i am afraid to say.

I would love to see anything of a peer review nature to say what we have is on the right track, the Edison type things that we pay for don't serve much purpose in my opinion for what they cost, i am sure the industry wont be impressed by them

We will have to see how they pose the update on the 23rd, but i for one would like to see a roadmap and why we have diverted away from the previous model, if it was working why did we do this, i feel after this many years we should be further forward with the drugs that we have and closer to a finishing line of some sort

Hi AndyMKDon, hope you are well, like you i have been here for well over 16 years and still believe in the actual product, however it might be the wider pharma community do not see the value as much as we do, especially after all this time?

If that is the case this latest move is indicative of masking that, the Ai investigation is exciting but it will still leave us with compounds that need testing, trial work and tox studies to even get to first base, this would be another lengthy process along with being very costly. We have reacquired 737 but that has gone quiet since that happened.

i must say i think they looked nervous in the interview rather than bullish. As everyone says the AGM could be interesting this year.

A proper update is in order for the loyal shareholder

Very much agree Benhowell, it would be lovely to actually get something finished and sold or licensed.

The CNS issue is all well and good but it seems to me we are kicking the same can further down the road with no real outcomes in sight and more investment needed. If it comes off all well and good but it would have been nice to put the autoimmune side of it to bed first and finish what you started, does this mean no one wants it for this, have they tried and failed and that is the reason for the change in focus?.

Salaries that were increased massively not long back still need to be paid and i find it disconcerting that we will have the same messages at the AGM again this year. With BOD members also going part time and no real succession plan in place that i can see we need more than dreams and hopes.

Edison videos are a very poor substitute for actual progress in my view, it is like marking your own homework and paying handsomely for the privilege. I think as shareholders we deserve more i am afraid.

If we were partnering with a larger Pharma company to do the CNS research i would be excited, but to do this on such a small scale i think it could take a very long time and the BOD will be the only winners as they are still paid however long it takes.

I think the house building analogy was spot on, lets concentrate on marketing what we have got instead of adding extensions etc and confusing the matter.

Would it not make more sense to tax the banks that we bailed out to the tune of billions not long back and are now campaigning for the rules to be relaxed again so they can get away with similar risky investments again and are no too big to fail, stop investing in projects like HS2 that have no foreseeable end date of fixed cost, recover some of the 5 billion that was scammed away in covid by people like michelle Mone who now lives in the lap of luxury at our expense alongside many others, this was supposed to have been rigorously chased, but still no outcomes and i guess there never will be , sorry for the rant but i am fed up of being the easy target just because i did work hard and had the good fortune to save and invest wisely

I hope you are all correct about the multiples that we may or may not achieve, it has been a very long road to here, my concern at the moment is that the AI introduction could, and i emphasise could, push the end game a lot further down the road in terms of proving and testing theories in order to secure a deal, this might suit the BOD as they continue to get the salaries , we would be the ones paying for this extra time, i hope not, but as i say this is my own concern.

I fully expect to be shot down in flames over this though

Rate cut does not appear to have helped the share price at all, it was only a minor reduction but at least it was in the right way. I would have hoped it might recover to at least 2.60 today on that news......................................

What do people think about there being an increase in shorts on L&G according to some news stories