RE: Interesting1 Nov 2021 21:51
Hi Ratty just a reminder shortly after these two jewels were published in peer reviewed journals (one of them American) Redmile become share holders they see the potential.
https://www.lse.co.uk/rns/SCLP/publication-highlights-potential-of-avidimab-hl98138qyipcdc0.html
https://www.lse.co.uk/rns/SCLP/new-publication-highlights-potential-of-modi-1-yqnjj8pqsx583hf.html
Peer reviewed publication highlights potential of AvidiMab™ to enhance the potency of any therapeutic antibody
Scancell Holdings plc, (AIM:SCLP), the developer of novel immunotherapies for the treatment of cancer, is pleased to note the publication of its manuscript in Cancer Research, a journal of the American Association of Cancer Research (AACR), entitled: "Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement".1
The paper describes how Scancell's AvidiMab™ modifications to the constant region (Fc) of any antibody can improve avidity, or strength of interaction, between the antibody and its target antigen, thereby improving the antibody's potential therapeutic properties. This same modification also has demonstrated that Scancell's own tumour-associated glycan (TaG) antibodies can directly kill tumour cells.
In recent years, antibodies have become the best-selling drugs in the pharmaceutical market and have been approved for treating various human diseases, including many cancers, autoimmune, metabolic and infectious diseases. The global therapeutic monoclonal antibody market is estimated to be US$150 billion in 2019 and predicted to grow to US$300 billion by 2025.2
The ability to increase the potential therapeutic properties of any antibody would therefore be seen as highly advantageous. Scancell has used its AvidiMab™ technology to increase the avidity of its TaG antibodies, and these are currently being evaluated for the treatment of cancer. They are also being developed as antibody-drug conjugates (ADC).3
Professor Lindy Durrant, Chief Scientific Officer of Scancell and Corresponding Author, commented:
"We are pleased to have our work published in the prestigious, peer reviewed journal, Cancer Research. Our AvidiMab™ technology increases the avidity of human antibodies by promoting non-covalent Fc-Fc interactions. This modification also causes direct killing of cancer cells by our glycan targeting antibodies, and therefore we believe this technology has the ability to create superior candidates for cancer immunotherapy."
$300 billion market by 2025 nice timing Redmile bring it on.