Member Info for Saxondale

Good to see Faron setting up on Twitter - finally some PR perhaps , and also making sure they have some visibility for news releases , and perhaps also see feedback they may get from both investors and interested parties .

Spotted this article that got published last week .
https://www.researchsquare.com/article/rs-732466/v2
relating to the INFORAAA trial
https://clinicaltrials.gov/ct2/show/NCT03119701

Interesting that the research article just published now .

This was the trial of IFN on patients surviving emergency open surgery for an infra-renal ruptured abdominal aortic aneurysm .

It was stopped due to safety as a drug/drug interaction caused issues - turned out to be steroids ( as we all now know ) .

The trial by the looks of it was not that easy to monitor effectively , what with the nature of the patients ( ie emergency situation ) , and also IFN was not able to be given pre surgery either ( due to blood loss etc)
High steroid use messed up the trial , but didn't explain all the failures - so more research needed beyond that one factor .

But this article links the symtoms of Covid into the mix too , on how IFN beta neutralizing antibodies blocked the up regulation of CD73 .

This article is a good read when trying to understand what HIBISCUS is trying to prove .
1.) That with steroids taken out of the mix , IFN will be more effective
2.) Early treatment with IFN may better than late treatment
3.) Treatment with steroids after IFN , not before or during , could also be beneficial

The INFORAAA trial was dealing with some pretty acutely ill patients , and the steroid mix looked to have proved pretty damaging when you have such severely ill patients .
The HIBISCUS trial has that combination risk factor eliminated , but does not avoid comparing steroid use against IFN .

Obviously the DofD have been working on this too over the past few years .
And see the justification for funding this new trial .

I'm sure I have read this trial info before , but not paid much attention as it wasn't looking at lungs . But to have the steroid issue with an organ trial , and a lung trial , certainly adds weight to the reason why HIBISCUS was approved by FDA in order to get proper clinical evidence on the steroid issue once and for all .

If I am getting this right , INFORAAA was already underway at the time INTEREST results came back , and they weren't aware that it was a steroid issue at that time , so INFORAAA just carried on running as it was , taking steroid patients in the mix , and getting a bad set of data .

If I had a spare £10,000 to put into either bitcoin or gold right today , I think I'd still pick gold .
I've dabbled in bitcoin , and never made anything , so probably biased because of that .
I see gold as a store of wealth and a safe harbour in a storm .
I see bitcoin as the same , but I still can't bring myself to see it as totally real . I understand it is finite , and has all the qualities that enable it to be used for payments etc , but at the end of the day it has been created out of thin air , and although everyone has their passwords and it's shows as being worth $$$ on a screen , I just can't bring myself to buy any as it just seems too unreal .
The fact its gone so high reflects also on how worthless FIAT currency is , and how faith in FIAT is dwindling .
In a free market , gold ( and silver )would be rocketing too .
Its just at the moment we are stuck with a load of bullion banks ( as you well know ) trying to shoot themselves out of a pickle , and the POG is stuck under their boot until they get free .
Good luck to the Bitcoin followers , in a way they may end up helping gold , as the more popular crypto gets , the more FIAT gets left behind .
People will always value things with scarcity , be it wine , works of art or precious metals .
It may well be , that in 10 years , I end up cashing a few brits in for crypto , not cash , as that's what I'll need to buy stuff .
Who knows lol !

And when asked where he sees any new growth from discoveries coming from , he says in his opinion their prime focus is on the Patterson and Havieron area to find them .

Well done Greatland . Watched the interview , liked the bit when the guy asked whats coming up , and Shaun said the next update will be worth looking out for , new drill hits and particularly the Eastern target zone . He's not going to big it up if its going to be a flop is he . 2 weeks till that .
Boy is he getting into his stride .

This reads really well .
Yes it's not confirmation of P3 , but sure does elaborate on how they see SNG001 .

Allowing protocols to adapt to both the situation , and to focus on the strengths of the potential therapy would just seem like common sense to most people .
The sort of thing most SNG investors wished could have been arranged before the trials began .
Looks like it's actually being done now !
And if we are into phase 3 , I think it shows that they are keen to make the most of it , to glean data for where SNG001 is the best fit .
Sprinter will do the job anyway - but its great to see Activ2 being constructive rather than obstructive .

No guarantee of anything , but reassuring that everything is being built up ready to go and with top people .

Senior pharma executive with over 30 years’ experience predominantly in global regulatory affairs, but including clinical research and commercial, gained in large and small Pharma as well as novel service companies.

Proven expertise at deriving and delivering regulatory affairs strategy for project portfolios across the lifecycle from late research/preclinical, through marketing authorisation to post-approval, in multiple therapeutic areas (including anti-infective, oncology, CNS and cardiovascular; biologics and NMEs,) and regions (EU, US and Japan). Particular expertise in leveraging regulatory strategy as a core business driver to accelerate patient access to innovative therapies.

Experienced industry leader and Board member in a variety of business models, including internal and external global resource management, financial management and HR. Co-founder and executive director of a global drug development services company (PLC).

I bet he looked in here and thought - ' my work here is done '
Mans a walking jinx .

SD is on fire again .
Growth , growth , growth .
Just bought some more ( and it took a while )

I think even the most cunning and mischievous peddlers of FUD are going to have a hard time of things from this day forth .

I like the subtle use of an iceberg on slide 3 as a background .
Says it all really

Only a fraction - as Shaun says - this is the entree leading into the main course .
Greatland Gold to become second lowest cost gold miner on the planet following Havieron PFS

Now that is a a juicy document to read !!
So happy being a GGP holder :-)

Well its where I'd expect it to be , a week after a placing at approx £3.30
It's not where I want it to be .
And not where i expected it to be a few weeks ago when I bought some at £4.72 either .

At least we are now funded - which means they can get on and progress the research , and also have a stronger hand should some partnering discussions finally make it to the point where pen meets paper .

The potential for big bucks here still as strong as ever . But until we get something concrete , its up and down as usual .

The market obviously saw the placing as a sign that no deal was imminent - hence the slide back .
Once they get a sniff of something in the wind , it'll soon come back mate .

But you have to expect the unexpected at Faron - good and bad .News could come from many sources this Autumn .

Quiet week here after all the activity last few weeks .
Yep G20 this weekend . Now up from 14 to 20 Healthcare companies presenting .
Would be interesting to know what they are pitching for ? Grants ? Access to Govt funding ?

Has to be a good thing whatever . Funding seems to be the biggest hurdle for the likes of Faron , that and the danger of being squeezed out or derailed by a larger competitor . So to be under the wing of the EIC & DofD already , and talking to the big boys from the G20 should hopefully keep us in the limelight and on their radar .

Been a bit frustrating having built up to ESMO etc , only to now be waiting again for something to fire us up .

Could be anything as usual , just have to be patient again I guess.

SP is where you'd expect it .

Just as a catch up -
Watch from 39 mins in - Dr Mario talks of safety data on Interferon.
This was back in Feb 11th 2021
https://www.youtube.com/watch?v=QIICw2HfQoM&t=2415s

I'm looking for the quote about applying for EUA too.

Did anyone see a Rick Rule interview on Stansberry Research on Weds .
He was talking about precious metal miners , and said it was like wanting to buy a coat that was $300 ( I read as GGP at 30p ) only to find the shop is selling it at $160 ( GGP at 16p , which it was on Weds ) . So he was helping himself as it were .
Coincidence I'm sure lol

Not sure if already been posted today but just a few more study sites added today on Sprinter Trial
One in each of the following :
Argentina
Columbia
India
Israel
Germany
Italy

Just housekeeping , but nice to see how global the effort is .

Yes all our best wishes to you JTMac . Soon be back on deck . We will need the full crew when sailing into harbour at treasure island .

Ndn , I think you might have mixed me up with someone else . I think everything Castro says is right .

Just watched the whole vid now .
Yes so he says firstly that the two drugs are moving forward ( SNG001 and the antibodies ) and one drug isnt ( pill) - as it didn't show efficacy . So from that I take it he is saying that ours is effective .
Then a few minutes later a question comes in - and he says they are waiting on the safety data on these two - so can't say that they are moving forward . Which is self explanatory . The safety side should be no hurdle at all given what we have seen so far .
So unless I have again got it wrong - sounds like the main question we were hanging on - is it effective enough to progress ? is yes .