RE: Lows?8 Jun 2021 19:59
People don't listen to the news that has already been given.
-Reported data on 0518 as a neo adjuvant monotherapy, with demonstrable tumor reduction from taking a few tablets. Further data is due on this and they are planning Part B.
-0518 collaboration with MSD for a combi treatment with the highest revenue drug in the world that can only be used in a limited number of patients. Phase 1B currently being run in 120 patients at 4different US sites for about 4 different solid tumours. This time they are looking specifically at clinical benefit as the 1st part was primarily safety data. This is a life saving treatment for Stage 4 cancer patients.
-Another 0518 collaboration set to start later in the year with Merck Kgaa and Pfizer with Bavencio which is the only approved 1st line maintenance treatment for bladder cancer. Again Bavencio doesn't always work and microbiome deficiencies have been shown to be a key factor.
-Currently running 0518 trial in pancreatic cancer with radiation therapy. Data due later in the year.
-MSD has a 5% stake, most of which was taken out when 4D entered a 2nd collaboration with them to discover vaccine candidates, with potential milestone payments up to $1bn. If MSD do take any of the vaccine candidates forward this would be an incredible validation of the Micro RX platform as a LBP drug discovery tool.
-Completed a P2 trial in Blautix with very promising topline data, and in yalks with FDA about designing a P3 trial. Can get approval purely on bowel habit as primary endpoint and this was where the data was strongest.
-Developing candidates for neurodegenerative disease, starting with Parkinsons. Invited on to scientific advisory board of Michael J Fox Foundation and working with Parkinsons UK for patient input in trial design.
Most of this stuff has been announced over the last 12-18 months.
As we know the market is only going to really sit up and pay attention when pivotal data is released or the company receives a significant payment.