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Good morning Lsesar.
Since we have been in discussions with interested parties, for what seems like an eternity, trial data would be shared with interested party.
Until.this data is known and confirmed very little can happen apart from very low ball offer.
My opinion for what it is worth is we will have absolutely no problems with daily doses up to 300mg.
Originally put as range from 12.5 mg to maximum of 1000 mg per person although therapeutic dosing giving mg per kg is the preferred means
Should we have a similar safety profile to Deucravacitinib with and increased efficacy in certain Indications, we will then not be tainted with black box warnings, it will leave us close to or at the top of auto immune inhibitor treatment.
In preclinical Sareum took SDC1801 to over 30 times treatment levels with no observed adverse effects.
Regards
Funnyguy,
Operational disadvantage?
Australian clinical trials far more efficient and cost effective than UK. Added bonus of tax advantages.
This in reality is advantageous as can be shown from around the 6 week application time to acceptance. 6 months later and the MHRA cannot even state what additional information they require.
With regards to the above, this has no effect whatsoever whether a drug will pass or fail its trial objective.
I did not see SO returning 737 but had a degree of concern with no development for a period of 18 months.
We have a new private company in the US for licence as released in the RNS. I bet you did not see that coming.
As for Riverfort finance, l must admit l did not see that coming along with its death spiral. Long term proper, positive investors took care of that with WRAP offer.
As for
'So, i tell you what let's reconvene when all the results are known and we know the next step, until then it's all conjecture. So regardless of your ability to copy and paste form medical journals what have you got?'
So you admit to it all being conjecture yet cannot see your blinding error with regards to posting waiting for confirmation of failed test for Sareum.
On top of the copy and paste medical journals, l do understand them to a great extent. I have spent 1000's of hours researching.
I expect good results on what l know. Preclinical trial was carried out with attention to detail. Reports given by qualified scientists!
On the other hand we have you.
You already see failure as clearly you do not know even when the outcome is not known.
Regards
Regards
Funnyguy.
Your claimed 'tuppence worth' after reading is not worth anywhere near that.
What you have based your statement on has absolutely nothing to do with a kinase inhibitors safety or efficacy.
What l will say is that SDC1801 in preclinical was tested to over 30 times therapeutic dose with no adverse effects encountered.
Efficacy in vitro and in vivo were reported good
This information readily available by qualified scientists and you think you know better than them
Knowledge is power and clearly you have very little of either.
Regards
Funnyguy it is not opinion when you post
'We are not too far away from confirmation that Sareum have failed the tests and will not pursue.'
The above implies known reported failure,
You are nothing more than a little liar.
MHRA has nothing to do with testing you imbecile.
To go to Australia for testing at huge disadvantage operationally to Sar.
Where has a statement been made either expressed or implied that their is any operational disadvantage here?
As for the result?
Based on your ' confirmation that Sareum have failed the tests and will not pursue'
You don't know yet deliberately put up misleading information.
As for asking you on what factual material you base such a statement you fail to give a satisfactory answer.
I did not ask where those that opinionated flying through trials or close to a licensing deal gain their information. I asked YOU, where you get your evidence.
There is no evidence to suggest that. It has sweet FA to do with MHRA going to Australia or anything.
Now educate yourself sonny and don't post opinion as a statement unless you can clearly back it up.
You have failed abysmally to get anywhere near a fraction of a satisfactory reply.
Being here, as you claim for over 10 years it is readily apparent you know very little. You certainly have not been on this LSE chatboard as Funnyguy for 10 years
One more thing sonny I do not look at the leader board to chose who or what l invest in.
As for deserving to lose money? I don't think people making investments whether they go long or short deserve to lose money.
Clearly you have a big chip on your shoulder, you have already sold out here at a small loss as stated by yourself.
Clearly my investment strategy is different to yours.
Regards
Funnyguy,
Not sure what you mean by 'deserve any money invested'
I have been here since Aug 2012.
A long journey yes, even longer than l thought.
Companies have their ups and downs. These ups and downs do not change what the company has.
I believe in what they have created.
As you have no belief in what the company has created as indicated by your posting history, then what on heavens name prompted you to invest?
Regards
Funnyguy.
Opinion is one thing misleading or false information is something else.
This stated by you a few days back, can you confirm this is correct?
'We are not too far away from confirmation that Sareum have failed the tests and will not pursue.
On what factual data or statements have you based your above post, to give any credibility?
Correct me if l am wrong that if you have no such information to rely on, as l believe, then you have posted misleading information but also false information.
Regards
DrMicho how much is that likely to cost?
Are you looking at Phase 2a or Phase 2a and 2b.
What is the Sareum strategy?
Why has Sareum chosen to go for phase2a and not phase 1b as initially planned?
Lot of newcomers on here clueless.
Regards
Investing genius. You have absolutely no idea.
250% time from a low 10p fund raise.
Dropping to 10p from its high is a 98% drop, positive news and still drops.
At 10p there would have to be a 5000% rise to bring it back to where it was.
At the moment around 1600% like needed.
It is not the 250% rise which is overdone it is the 98% due to worldwide events and a pi55 poor death spiral finance.
News is due on data results anytime soon.
How would you place a value on a Tyk2 Jak1 inhibitor commencing phase2 clinical trials?
Regards
Nicely, goodmorning.
A post here from funnyguy, how much of this one you agree with, and like funnyguy on what basis do you make such an absurd statement?
'Unbelievable 13 Mar 2024 21:24
That people on here is talking up the science of Sareum. If this was a grand national Sareum have barely jumped the first fence and people are saying we have a champion.
Forget the testing, follow the finance and your answer is there. We are not too far away from confirmation that Sareum have failed the tests and will not pursue. Use your brains. This is all a nod to the people that really matter, the financial sector and HWNI. don't be fooled into thinking that Sareum have small private investors interest at heart. They have been played so will now play us and the executives involved do not know how to play this game so are easy pickings for the professionals.
Expect SAR to go bust this year. I pulled out with a small loss'
THAT SAYS IT ALL ABOUT THE INDIVIDUAL.
'confirmation that Sareum have failed the tests and will not pursue.'
What a complete load of unsubstantiated bs, it don't know, has no idea.
Funny Guy.
No, we are most certainly not in the same situation, as Riverfort will no longer demand shares to pay outstanding debt.
Had WRAP not gone ahead we would have been well and truly shafted.
Riverfort gave an opportunity to buy but by their own actions created a situation of being unable to draw down further funding.
So there you are as an investor you come in buying on the way down and end up with a situation where the company is in severe financial
problems. Riverfort don't give a damn about any investors here.
As for name sonny, it does not say it all. You need grow up! Take your piddly 6k out and get a life.
Dunny Guy if that is your conclusion that Riverfort gave us an opportunity to make some quick money that just about sums you up.
Had the people here not made an effort to put forward a solution to death spiral finance, where would be?
Sareum had no money and Riverfort cannot lend to Sareum under the terms of the finance contract.
However, you can put your last dollar on what Riverfort's next action would have been. Finance the company in the form of a loan and take ownership of the company.
You would have preferred this outcome?
I should think a lot of people have to laugh at your posts,
Bought 33,000 shares which now makes your average what? As was 61 p?
You have sold a few shares on a spike this am and like 1 or 2 others on here paint a negative view to feed their own agenda?
On top of that you have not been here 2 minutes and know Jack 5hit.
You have similarities with Riverfort,
Only a few weeks before news lands and you want to trash the share.
You want trash the share like RF buy in then sell on another spike before going back to trashing the share again.
What a prawn!
Regards
Rf most likely forward sell shares as they have done recently. However they may ease release rate to capitalise on gain. Warrants they have 4 years and early tranche was for them to buy at 147p.
Shares will become scarce soon and we are leading up to news time.
Riverfort having a few options is no problem, A company choosing to on license pr partnership will not touch us with a barge pole.
At the moment just be patient for the SP to rerate itself in the 70 to 75 million market cap.
A few weeks is all!
Regards
Nicely you have no confidence on this share at all. You write rubbish too.
You average for SAR was 4 pound 70.
How on earth you manage that?
Caught on a spike?
100k down on this share?
100k down on another share too you claim?
You are a MAJW&CO disciple me thinks.
Regards
Not volume as such. You cannot use the drawdown facility at more than 1 million debt balance. The amount owing with drawdown cannot be greater than 10% of market cap.
Manipulated to create financial chaos.
I should think they looked at the detail in the small print am sure even Stevie Wonder could have found it.
Regards
Not volume as such. You cannot use the drawdown facility at more than 1 million debt balance. The amount owing with drawdown cannot be greater than 10% of market cap.
Manipulated to create financial chaos.
I should think they looked at the detail in the small print am sure even Stevie Wonder could have found it.
Regards