Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
Although more applicable to 1802 it is worth having a quick read of link below regarding MTD.
https://www.pharmaceutical-technology.com/features/fda-drug-dosage-optimisation-guidelines-signal-clinical-trial-reform/?cf-view
Just an enlightened here.
What is the advantage of phase 2a over phase1b?
There is a degree of similarity in the to a certain extent both these trials achieve the same thing.
Effectively proof of concept that the inhibitor is or will likely provide a viable therapeutic treatment for Psoroasis.
Phase 1 trial establishes safety profile.
Phase 1b small number of patients up to several 10's
Can be no increase in therapeutic treatment, basically no exceeding 300mg per day. I doubt we would need anywhere near 30 mg per day anyhow for Psoriasis.
Phase 2a similar number of patients as to Phase 1b. Proof of concept.
Phase 2b, a larger number of patients normally around a couple if hundred. Increased dosaging v effectiveness here. The purpose of this Phase is to establish statistical data ( accuracy is related to the magnitude of count) that will indicate to a certain degree not only the tolerability, safety, but also efficacy.
When all proceeds fine then progression to phase 3 typically involving 1 to 2 thousand people.
At this stage, we are looking at long term effects and the evaluation of the compound continues dnd if this particular compound exceeds the safety and efficacy of the current standard of care, then apply for clinical approval.
Phase 2 by the very nature will have far more clout and add value as you have gone from phase 1 to phase 2.
Phase1b cab be put into progress znd whilst progressing plans can be made, via whatever means onlicence, partnership, or buyout can be decided on.
Regards
Apologies if a few mistakes as mobile phone misbehaving. It not allow me to read through.
Hbd,
I don't think takeover likely until development of 737 established.
It has potential and indeed once in combo has been found then it has a value.
Hard to treat cancers ie HGSOC being one.
Market is huge and still an area of unmet need.
Difficult to evaluate. Held back l believe by SO as a secondary measure to ensure no competition to the likes of the GSK pipeline.
Most know my views on this one.
SDC1801 safety data imperative and should we escape the dreaded black box warnings then that pits us at or very near the top of all else out there.
Phase2 is the way forward.
Phase 2 is way worth more than phase 1b.
Phase 1b will prove point of concept,however Phase 2 will establish most effective dosages.
Phase 1b we cannot progress beyond 300mg per day.
Plus there are other Indications of which some we will be best at. These need identifying.
All looks good as l see it.
Nearest competitor as l see it is Ropsacitinib a tyk2 jak2 inhibitor. Ok if the Tyk2 pairs with Jak 2 and hence control on iL 23 but jak2 is associated with EPO when paired with itself so concerns here will arise as basically one of the adverse side effects resulting in the Jaki black box warnings.
Will have a look, but not have lap top and hence stuck with poxy little mobile phone and not the enormous amount of saved research data on hand.
Next week l see SP in the region of 35 to 40p.
I may be wrong and what we have is day traders and nor investors as such. Most will sell once a profit of a few per cent is established.
Regards to all
Do you know Salfordred, l think to save money and make good for the share holder.
Equity finance, finance secured and trail can progress.
I think Tim and in the belief that as finance available and progress is made, subsequent drawdown is off set by an increase in SP
Ok, but in the event when shares placed on the market exceeding the demand the SP will fall.
This of course can be manipulated.
Same unfortunately with CTA application.
Strange that they seek independent world class specialists to investigate and trial our drug, but at the same time, finance and specialists knowledge equally important that have tried to resolve them selves. False economy.
We will grow from here.
Regards
I am ddep in thought as have circa 30k to put in. Do l buy now on a low?
Do l wait see if further money raise?
Do l go 50 50?
Will buy l think on this dip? If it goes past 32 p then sell 75% of newly acquired
15% drop then increase by 25% on top of the money taken from 75% sell
Need be careful as good news is due and round be better to know how Sareum chose to play the game.
Anyhow, Billy at the top with largest share holder value. In essence we are all in the same game irrespective of the shares we own.
If we all pull in the same direction then we will all be on to a winner.
Recently there has been a a few of the extremely disruptive poster. Started around Aug 6th. Just a few with an agenda that will stir up.
Not all bad for them as we have berks here quite happy to pay for a statue for them.
Regards to all the genuine
Good morning Lsesar.
Since we have been in discussions with interested parties, for what seems like an eternity, trial data would be shared with interested party.
Until.this data is known and confirmed very little can happen apart from very low ball offer.
My opinion for what it is worth is we will have absolutely no problems with daily doses up to 300mg.
Originally put as range from 12.5 mg to maximum of 1000 mg per person although therapeutic dosing giving mg per kg is the preferred means
Should we have a similar safety profile to Deucravacitinib with and increased efficacy in certain Indications, we will then not be tainted with black box warnings, it will leave us close to or at the top of auto immune inhibitor treatment.
In preclinical Sareum took SDC1801 to over 30 times treatment levels with no observed adverse effects.
Regards
Funnyguy,
Operational disadvantage?
Australian clinical trials far more efficient and cost effective than UK. Added bonus of tax advantages.
This in reality is advantageous as can be shown from around the 6 week application time to acceptance. 6 months later and the MHRA cannot even state what additional information they require.
With regards to the above, this has no effect whatsoever whether a drug will pass or fail its trial objective.
I did not see SO returning 737 but had a degree of concern with no development for a period of 18 months.
We have a new private company in the US for licence as released in the RNS. I bet you did not see that coming.
As for Riverfort finance, l must admit l did not see that coming along with its death spiral. Long term proper, positive investors took care of that with WRAP offer.
As for
'So, i tell you what let's reconvene when all the results are known and we know the next step, until then it's all conjecture. So regardless of your ability to copy and paste form medical journals what have you got?'
So you admit to it all being conjecture yet cannot see your blinding error with regards to posting waiting for confirmation of failed test for Sareum.
On top of the copy and paste medical journals, l do understand them to a great extent. I have spent 1000's of hours researching.
I expect good results on what l know. Preclinical trial was carried out with attention to detail. Reports given by qualified scientists!
On the other hand we have you.
You already see failure as clearly you do not know even when the outcome is not known.
Regards
Regards
Funnyguy.
Your claimed 'tuppence worth' after reading is not worth anywhere near that.
What you have based your statement on has absolutely nothing to do with a kinase inhibitors safety or efficacy.
What l will say is that SDC1801 in preclinical was tested to over 30 times therapeutic dose with no adverse effects encountered.
Efficacy in vitro and in vivo were reported good
This information readily available by qualified scientists and you think you know better than them
Knowledge is power and clearly you have very little of either.
Regards
Funnyguy it is not opinion when you post
'We are not too far away from confirmation that Sareum have failed the tests and will not pursue.'
The above implies known reported failure,
You are nothing more than a little liar.
MHRA has nothing to do with testing you imbecile.
To go to Australia for testing at huge disadvantage operationally to Sar.
Where has a statement been made either expressed or implied that their is any operational disadvantage here?
As for the result?
Based on your ' confirmation that Sareum have failed the tests and will not pursue'
You don't know yet deliberately put up misleading information.
As for asking you on what factual material you base such a statement you fail to give a satisfactory answer.
I did not ask where those that opinionated flying through trials or close to a licensing deal gain their information. I asked YOU, where you get your evidence.
There is no evidence to suggest that. It has sweet FA to do with MHRA going to Australia or anything.
Now educate yourself sonny and don't post opinion as a statement unless you can clearly back it up.
You have failed abysmally to get anywhere near a fraction of a satisfactory reply.
Being here, as you claim for over 10 years it is readily apparent you know very little. You certainly have not been on this LSE chatboard as Funnyguy for 10 years
One more thing sonny I do not look at the leader board to chose who or what l invest in.
As for deserving to lose money? I don't think people making investments whether they go long or short deserve to lose money.
Clearly you have a big chip on your shoulder, you have already sold out here at a small loss as stated by yourself.
Clearly my investment strategy is different to yours.
Regards
Funnyguy,
Not sure what you mean by 'deserve any money invested'
I have been here since Aug 2012.
A long journey yes, even longer than l thought.
Companies have their ups and downs. These ups and downs do not change what the company has.
I believe in what they have created.
As you have no belief in what the company has created as indicated by your posting history, then what on heavens name prompted you to invest?
Regards
Funnyguy.
Opinion is one thing misleading or false information is something else.
This stated by you a few days back, can you confirm this is correct?
'We are not too far away from confirmation that Sareum have failed the tests and will not pursue.
On what factual data or statements have you based your above post, to give any credibility?
Correct me if l am wrong that if you have no such information to rely on, as l believe, then you have posted misleading information but also false information.
Regards
DrMicho how much is that likely to cost?
Are you looking at Phase 2a or Phase 2a and 2b.
What is the Sareum strategy?
Why has Sareum chosen to go for phase2a and not phase 1b as initially planned?
Lot of newcomers on here clueless.
Regards
Investing genius. You have absolutely no idea.
250% time from a low 10p fund raise.
Dropping to 10p from its high is a 98% drop, positive news and still drops.
At 10p there would have to be a 5000% rise to bring it back to where it was.
At the moment around 1600% like needed.
It is not the 250% rise which is overdone it is the 98% due to worldwide events and a pi55 poor death spiral finance.
News is due on data results anytime soon.
How would you place a value on a Tyk2 Jak1 inhibitor commencing phase2 clinical trials?
Regards
Nicely, goodmorning.
A post here from funnyguy, how much of this one you agree with, and like funnyguy on what basis do you make such an absurd statement?
'Unbelievable 13 Mar 2024 21:24
That people on here is talking up the science of Sareum. If this was a grand national Sareum have barely jumped the first fence and people are saying we have a champion.
Forget the testing, follow the finance and your answer is there. We are not too far away from confirmation that Sareum have failed the tests and will not pursue. Use your brains. This is all a nod to the people that really matter, the financial sector and HWNI. don't be fooled into thinking that Sareum have small private investors interest at heart. They have been played so will now play us and the executives involved do not know how to play this game so are easy pickings for the professionals.
Expect SAR to go bust this year. I pulled out with a small loss'
THAT SAYS IT ALL ABOUT THE INDIVIDUAL.
'confirmation that Sareum have failed the tests and will not pursue.'
What a complete load of unsubstantiated bs, it don't know, has no idea.
Funny Guy.
No, we are most certainly not in the same situation, as Riverfort will no longer demand shares to pay outstanding debt.
Had WRAP not gone ahead we would have been well and truly shafted.
Riverfort gave an opportunity to buy but by their own actions created a situation of being unable to draw down further funding.
So there you are as an investor you come in buying on the way down and end up with a situation where the company is in severe financial
problems. Riverfort don't give a damn about any investors here.
As for name sonny, it does not say it all. You need grow up! Take your piddly 6k out and get a life.
Dunny Guy if that is your conclusion that Riverfort gave us an opportunity to make some quick money that just about sums you up.
Had the people here not made an effort to put forward a solution to death spiral finance, where would be?
Sareum had no money and Riverfort cannot lend to Sareum under the terms of the finance contract.
However, you can put your last dollar on what Riverfort's next action would have been. Finance the company in the form of a loan and take ownership of the company.
You would have preferred this outcome?
I should think a lot of people have to laugh at your posts,
Bought 33,000 shares which now makes your average what? As was 61 p?
You have sold a few shares on a spike this am and like 1 or 2 others on here paint a negative view to feed their own agenda?
On top of that you have not been here 2 minutes and know Jack 5hit.
You have similarities with Riverfort,
Only a few weeks before news lands and you want to trash the share.
You want trash the share like RF buy in then sell on another spike before going back to trashing the share again.
What a prawn!
Regards