Ryan Mee, CEO of Fulcrum Metals, reviews FY23 and progress on the Gold Tailings Hub in Canada. Watch the video here.
Good evening Num4.
You can have the best product in the world but if it is not marketed correctly no one will ever know.
I have no doubts that 1801 in some areas will stand head and shoulders over most other kinase inhibitors out there at the current time.
Attention to detail yes.
Marketing? It is portrayed as an also ran.
It lacks vigour and let's face it the positive reports we do get are a little drab. Far from attention grabbing.
Good evening Num4.
Yes remember the event pretty well.
Sdc compounds. Similar albeit not identical compounds.
A patent was granted for one compound and there was difficulty in obtaining a patent in the other due to their similarity.
However it was granted as one was for use in immuno oncology and the other was cleverly patented for use in immunotherapy.
Interesting now as SDC1802 is now gaining patent protection in differing regions of the world with a patent protectecting it in its use for immuno therapy!
Clearly both compounds are good and who is to say that SDC1802 would not work better in IBD than 1801?
Regarding the MHRA a preclinical requirement prior to clinical trial application is that an MTD to be established.
As Tboth2 said many moons back it can be accepted without a maximum tolerated dose established as a threshold had been exceeded at 30 times treatment dose with no adverse effects
As Tim remarked in his interview with the smooth talking Aussie Andrew Scott.
'We have been unable to establish a maximum tolerated dose at 30 times and we mat need to go as high as 100 times,
'A nice problem to have 'said Tim and it may come back to bite us.
A well put together post you have compiled there Num4 l am entirely in agreement with that you have written.
Regards
Regards
Regards
Good evening C79
Top end Tyk2 Jak1 inhibitors will be worth a fortune.
No reason as yet as why we will not be best in Psoriasis and one or 2 other Indications.
There will exist companies that will want it for next to nothing.
Regards
Potnak l have increased my holding by around 25% by using WRAP.
Funds need to be raised.
The offer was 30% percent below current market value at the time.
I do congratulate myself, shares are cheap and in no way has it decimated the market cap as with the RF finance.
Tell me what other option the BoD has to raise funds.
Dilution has been going on since we had an original 800 million shares in old money years ago.
Money has been raised by various share placings since.
Regards
The extended WRAP has raised significant funds.
This must be a magnitude of order better than than pumping shares into RF finance shafting
Dilution is inevitable as funds are needed for further development. The BoD have added.
Much better to have funds with a tad more dilution than insufficient to complete phase 1a.
The Jan 2nd RNS was positive, today's RNS's both positive. The SP starts to climb and bang in come RF.
A deliberate suppression of the SP.
Who are they in bed with?
Regards
Ph came aboard and they managed to drop the price from just over 6p to just under 3p in a day.
Only been aboard a day or so.
No reason at all.
Price picked up slightly and settled over the next day or so.
Submissions to made by 11am.
That is H&L
If you not already hold account with them with Sareum shares l not have a scooby.
Short application period, bank holiday weekend not give much time to prepare.
Regards