RE: Rns31 Mar 2025 08:32
What are Topoisomerases?
Topoisomerases are enzymes that play a crucial role in maintaining the structure and function of DNA by unwinding and rewinding DNA strands during replication and transcription.
How Topoisomerase Inhibitors Work:
These inhibitors interfere with the activity of topoisomerases, preventing them from properly unwinding or re-winding DNA, leading to the accumulation of DNA damage and ultimately cell death.
Types of Topoisomerase Inhibitors:
Topoisomerase I Inhibitors: These inhibitors target topoisomerase I, an enzyme involved in single-strand DNA breaks, and include drugs like irinotecan and topotecan.
Topoisomerase II Inhibitors: These inhibitors target topoisomerase II, an enzyme involved in double-strand DNA breaks, and include drugs like etoposide, doxorubicin, and teniposide.